Quantifying cell behaviors in animal early embryogenesis remains a challenging issue
requiring in toto imaging and automated image analysis. We designed a framework for imaging …

Toxicity is one of the major attrition causes during the drug development process. In that line,
cardio-, neuro-, and hepatotoxicities are among the main reasons behind the retirement of …

… standard, and counting the correct links from t to t−1. Mitosis detection was also assessed …
each: from t=0 to t=20 (corresponding to 4.36±0.18 hpf), from t=100 to t=120 (6.22 hpf), from …

Investigating neural stem cell (NSC) behaviour in vivo, which is a major area of research,
requires NSC models to be developed. We carried out a multilevel characterisation of the …

A gene expression atlas is an essential resource to quantify and understand the multiscale
processes of embryogenesis in time and space. The automated reconstruction of a prototypic …

10.7554/eLife.22268.001 Reconstructing the lineage of cells is central to understanding
how the wide diversity of cell types develops. Here, we provide the neurosensory lineage …

… However, by neural keel stages (12–13 hpf), cdh2/pac mutants display abnormal neural
plate internalisation leading to a consistent and highly-reproducible aberrant T-shape or “…

We conducted a quantitative comparison of developing sea urchin embryos based on the
analysis of five digital specimens obtained by automatic processing of in toto 3D+ time image …

… On the other hand, 3D + t watershed only needs seeds to be specified at one frame, t = 11 in
… and 3D + t watershed algorithms are performed using a unit 3D sphere and a 3D + t hyper-…

… has been coupled with the MOVIT validation interface (Savy et al., unpublished). In the …
SHG signal intensity profile during mitosis; chromosomes separate at t = 0. The maximum of …