User profiles for T. Pradhan-Sundd

Tirthadipa Pradhan-Sundd

Associate Investigator, Versiti Blood Research Institute
Verified email at versiti.org
Cited by 870

[HTML][HTML] Blood–bile barrier: Morphology, regulation, and pathophysiology

T Pradhan-Sundd, SP Monga - Gene Expression, 2019 - ncbi.nlm.nih.gov
The term blood–bile barrier (BBlB) refers to the physical structure within a hepatic lobule that
compartmentalizes and hence segregates sinusoidal blood from canalicular bile. Thus, this …

Liver-to-lung microembolic NETs promote gasdermin D–dependent inflammatory lung injury in sickle cell disease

…, J Tejero, EM Novelli, T Pradhan-Sundd… - Blood, The Journal …, 2022 - ashpublications.org
Acute lung injury, referred to as the acute chest syndrome, is a major cause of morbidity and
mortality in patients with sickle cell disease (SCD), which often occurs in the setting of a vaso…

[PDF][PDF] Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by β-catenin mutations

…, H Yang, M Xu, JO Russell, T Pradhan-Sundd… - Cell metabolism, 2019 - cell.com
Based on their lobule location, hepatocytes display differential gene expression, including
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …

[PDF][PDF] Transient Fcho1/2⋅ Eps15/R⋅ AP-2 nanoclusters prime the AP-2 clathrin adaptor for cargo binding

…, AJ McCoy, SS Holkar, A Jha, T Pradhan-Sundd… - Developmental Cell, 2016 - cell.com
Clathrin-coated vesicles form by rapid assembly of discrete coat constituents into a cargo-sorting
lattice. How the sequential phases of coat construction are choreographed is unclear, …

[HTML][HTML] Exploring the complex role of coagulation factor VIII in chronic liver disease

T Pradhan-Sundd, S Gudapati, TW Kaminski… - Cellular and Molecular …, 2021 - Elsevier
Chronic liver disease is one of the leading causes of death in the United States. Coagulopathy
is often a sequela of chronic liver disease, however the role and regulation of coagulation …

Platelet extracellular vesicles drive inflammasome–IL-1β–dependent lung injury in sickle cell disease

…, MA Jimenez, T Pradhan-Sundd… - American Journal of …, 2020 - atsjournals.org
Rationale: Intraerythrocytic polymerization of Hb S promotes hemolysis and vasoocclusive
events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–…

Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice

T Pradhan-Sundd, R Vats, JO Russell, S Singh… - Gastroenterology, 2018 - Elsevier
… drafting of the manuscript: Tirthadipa Pradhan-Sundd, Satdarshan Pal Monga, … Pradhan-Sundd,
Satdarshan Pal Monga, and Prithu Sundd; statistical analysis: Tirthadipa Pradhan-Sundd

Redox signaling in sickle cell disease

D Nolfi-Donegan, T Pradhan-Sundd… - Current opinion in …, 2019 - Elsevier
Sickle cell disease (SCD) is characterized by chronic hemolysis and repeated episodes of
vascular occlusion leading to progressive organ injury. A dominant pathologic feature of SCD …

[PDF][PDF] Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis

T PradhanSundd, L Zhou, R Vats, A Jiang… - …, 2018 - Wiley Online Library
β‐Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic
development, regeneration, and tumorigenesis. However, its role at hepatocyte adherens …

[HTML][HTML] Platelet-derived growth factor receptor α contributes to human hepatic stellate cell proliferation and migration

A Kikuchi, T Pradhan-Sundd, S Singh… - The American journal of …, 2017 - Elsevier
Platelet-derived growth factor receptor α (PDGFRα), a tyrosine kinase receptor, is up-regulated
in hepatic stellate cells (HSCs) during chronic liver injury. HSCs mediate hepatic fibrosis …