User profiles for T. Pradhan-Sundd
Tirthadipa Pradhan-SunddAssociate Investigator, Versiti Blood Research Institute Verified email at versiti.org Cited by 870 |
[HTML][HTML] Blood–bile barrier: Morphology, regulation, and pathophysiology
T Pradhan-Sundd, SP Monga - Gene Expression, 2019 - ncbi.nlm.nih.gov
The term blood–bile barrier (BBlB) refers to the physical structure within a hepatic lobule that
compartmentalizes and hence segregates sinusoidal blood from canalicular bile. Thus, this …
compartmentalizes and hence segregates sinusoidal blood from canalicular bile. Thus, this …
Liver-to-lung microembolic NETs promote gasdermin D–dependent inflammatory lung injury in sickle cell disease
Acute lung injury, referred to as the acute chest syndrome, is a major cause of morbidity and
mortality in patients with sickle cell disease (SCD), which often occurs in the setting of a vaso…
mortality in patients with sickle cell disease (SCD), which often occurs in the setting of a vaso…
[PDF][PDF] Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by β-catenin mutations
…, H Yang, M Xu, JO Russell, T Pradhan-Sundd… - Cell metabolism, 2019 - cell.com
Based on their lobule location, hepatocytes display differential gene expression, including
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …
pericentral hepatocytes that surround the central vein, which are marked by Wnt-β-catenin …
[PDF][PDF] Transient Fcho1/2⋅ Eps15/R⋅ AP-2 nanoclusters prime the AP-2 clathrin adaptor for cargo binding
…, AJ McCoy, SS Holkar, A Jha, T Pradhan-Sundd… - Developmental Cell, 2016 - cell.com
Clathrin-coated vesicles form by rapid assembly of discrete coat constituents into a cargo-sorting
lattice. How the sequential phases of coat construction are choreographed is unclear, …
lattice. How the sequential phases of coat construction are choreographed is unclear, …
[HTML][HTML] Exploring the complex role of coagulation factor VIII in chronic liver disease
T Pradhan-Sundd, S Gudapati, TW Kaminski… - Cellular and Molecular …, 2021 - Elsevier
Chronic liver disease is one of the leading causes of death in the United States. Coagulopathy
is often a sequela of chronic liver disease, however the role and regulation of coagulation …
is often a sequela of chronic liver disease, however the role and regulation of coagulation …
Platelet extracellular vesicles drive inflammasome–IL-1β–dependent lung injury in sickle cell disease
…, MA Jimenez, T Pradhan-Sundd… - American Journal of …, 2020 - atsjournals.org
Rationale: Intraerythrocytic polymerization of Hb S promotes hemolysis and vasoocclusive
events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–…
events in the microvasculature of patients with sickle cell disease (SCD). Although platelet–…
Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice
T Pradhan-Sundd, R Vats, JO Russell, S Singh… - Gastroenterology, 2018 - Elsevier
… drafting of the manuscript: Tirthadipa Pradhan-Sundd, Satdarshan Pal Monga, … Pradhan-Sundd,
Satdarshan Pal Monga, and Prithu Sundd; statistical analysis: Tirthadipa Pradhan-Sundd…
Satdarshan Pal Monga, and Prithu Sundd; statistical analysis: Tirthadipa Pradhan-Sundd…
Redox signaling in sickle cell disease
D Nolfi-Donegan, T Pradhan-Sundd… - Current opinion in …, 2019 - Elsevier
Sickle cell disease (SCD) is characterized by chronic hemolysis and repeated episodes of
vascular occlusion leading to progressive organ injury. A dominant pathologic feature of SCD …
vascular occlusion leading to progressive organ injury. A dominant pathologic feature of SCD …
[PDF][PDF] Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis
T Pradhan‐Sundd, L Zhou, R Vats, A Jiang… - …, 2018 - Wiley Online Library
β‐Catenin, the downstream effector of the Wnt signaling, plays important roles in hepatic
development, regeneration, and tumorigenesis. However, its role at hepatocyte adherens …
development, regeneration, and tumorigenesis. However, its role at hepatocyte adherens …
[HTML][HTML] Platelet-derived growth factor receptor α contributes to human hepatic stellate cell proliferation and migration
A Kikuchi, T Pradhan-Sundd, S Singh… - The American journal of …, 2017 - Elsevier
Platelet-derived growth factor receptor α (PDGFRα), a tyrosine kinase receptor, is up-regulated
in hepatic stellate cells (HSCs) during chronic liver injury. HSCs mediate hepatic fibrosis …
in hepatic stellate cells (HSCs) during chronic liver injury. HSCs mediate hepatic fibrosis …