The targets of the Structural GenomiX (SGX) bacterial genomics project were proteins
conserved in multiple prokaryotic organisms with no obvious sequence homolog in the Protein …

The hydrolytic haloalkane dehalogenases are promising bioremediation and biocatalytic
agents. Two general classes of dehalogenases have been reported from Xanthobacter and …

Calcitonin gene-related peptide (CGRP) is a widely expressed neuropeptide that has a major
role in sensory neurotransmission. The CGRP receptor is a heterodimer of the calcitonin …

Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin
organization and function 1 . Among the genes coding for the MYST family of KATs (KAT5–KAT8) …

Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of
fungal growth and contribute to serious health problems in the developing world because of …

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional
dysregulation that results in a block in differentiation and increased malignant self-renewal. …

Carbonic anhydrase IX (CA IX) is a target for hypoxic cancer therapies, and the discovery of
CA IX selective ligands is imperative for the development of these agents. Primary …

We present a new approach to carbonic anhydrase II (CA II) inhibitor design that enables
close interrogation of the regions of the CA active site where there is the greatest variability in …

This study forms an initial investigation into the development of SprayStir, an innovative
processing technique for generating erosion resistant surface layers on a chosen substrate …

We have identified a virus, B/Perth/211/2001, with a spontaneous mutation, D197E in the
neuraminidase (NA), which confers cross-resistance to all NA inhibitors. We analyzed enzyme …