Genomes are more than linear sequences. In vivo they exist as elaborate physical structures,
and their functional properties are strongly determined by their cellular organization. I …

… I thank members of the Misteli lab and numerous colleagues in the field for critical and
constructive input. I thank Erina He, NIH Medical Arts, for creating the figures. Work in the Misteli …

Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

Activated RAS promotes dimerization of members of the RAF kinase family 1 , 2 , 3 . ATP-competitive
RAF inhibitors activate ERK signalling 4 , 5 , 6 , 7 by transactivating RAF dimers 4 . …

… Similar results were obtained using Student's t-test on the MPO amounts of mice that were
… Phair, RD & Misteli, T. High mobility of proteins in the mammalian cell nucleus. Nature 404, …

Differentiation of embryonic stem (ES) cells from a pluripotent to a committed state involves
global changes in genome expression patterns. Gene activity is critically determined by …

… T 0 is total cellular intensity during prebleach, T t the total cellular intensity at timepoint t, I 0
… pre-bleach, I t the average intensity in the region of interest in timepoint t. This expression …

… The most prevalent HGPS mutation (heterozygous Gly 608 →Gly 608 with C changed to T)
leads to a splicing defect and consequent generation of a truncated, dominant gain-of-…

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet
its regulation is poorly understood. We demonstrated a direct role for histone modifications …

… The time to reach 80% of the prebleach intensity (t 80 ) for GFP-HP1ΔCD and GFP-HP1-V23M
was 300 ms and 420 ms, respectively, in euchromatin compared with a t 80 of 780 ms for …