Everyone ages, but only some will develop a neurodegenerative disorder in the process.
Disease might occur when cells fail to respond adaptively to age-related increases in oxidative, …

… -like T cells such as γδ T cells and CD (cluster of differentiation) 8+ cytotoxic T cells also
arrive early, 25 while conventional CD4 T cells arrive in a time window similar to neutrophils. T …

… P2X7 activation also leads to alterations of the T-cell surface and can even cause T-cell
death in the case of prolonged stimulation. In contrast to ATP, adenosine, the end product of …

… NKT cells are a subset of T-cells that coexpress an αβ-T-cell … clonal deletion of T-lymphocytes
and activates regulatory T-cells… supported by the observed failure in T-cell activation in our …

… However, recent evidence suggests that TLRs are activated in immune cells (T cells, dendritic
cells, and macrophages) in response to tissue injury, including trauma, hemorrhagic shock…

… αβ and γδ T cells in a murine model of stroke and distinguished 2 different T cell–dependent
proinflammatory pathways in ischemia-reperfusion injury. IFN-γ produced by CD4 + T cells …

Multi-protein complexes called inflammasomes have recently been identified and shown to
contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-…

… Notch can activate T lymphocytes, resulting in cell proliferation and cytokine production
14 , and our data suggest an important role for Notch in the activation and recruitment of …

Predicting the rate of disease progression has become important as trials of new medical
treatments for amyotrophic lateral sclerosis (ALS) are planned. Bulbar onset, early impairment …

Stroke is among the three leading causes of death worldwide and the most frequent cause of
permanent disability. Brain ischemia induces an inflammatory response involving activated …