… scRNA-seq is also ideal for examination of single cells where each one is essentially unique,
such as individual T lymphocytes expressing highly diverse T-cell receptors [20], neurons …

… These cells are crucial in purging autoreactive T cells and promoting development of
thymic regulatory T cells by ‘projecting an immunological self shadow’ through systematic …

… By analyzing the CD4 + T cells in a clustering-independent method by selecting all cells that
… of single T H -specific transcription factors, we find that a large population of T cells did not …

… trajectories of T H 1 and T FH (T follicular helper) cells during … T cell receptor sequences, we
first demonstrated that T H 1/T … associated with T H 1 or T FH fates and demonstrated a T cell…

Nucleic acids that store and transfer biological information are polymeric diesters of phosphoric
acid. Cleavage of the phosphodiester linkages by protein enzymes, nucleases, is one of …

We developed TraCeR, a computational method to reconstruct full-length, paired T cell
receptor (TCR) sequences from T lymphocyte single-cell RNA sequence data. TraCeR links T …

… The highest LAG3 expression was noted in NK cells, Tregs, and CD8 + T cells, and these cell
… , and their expanding CD8 + T cell clones gained a more cytotoxic and NK-like phenotype. …

Lymphatic vessels form a critical component in the regulation of human health and disease.
While their functional significance is increasingly being recognized, the comprehensive …

Rationale: Genome-wide association studies have identified hundreds of loci associated with
coronary artery disease (CAD). Many of these loci are enriched in cisregulatory elements …

Naive CD4 + T cells can differentiate into specific helper and regulatory T cell lineages in
order to combat infection and disease. The correct response to cytokines and a controlled …