The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero.
This lineage is specified before implantation into the uterus and is restricted to form the fetal …

Pluripotent embryonic stem (ES) cells must select between alternative fates of self-replication
and lineage commitment during continuous proliferation. Here, we delineate the role of …

A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for
study. One solution is to derive induced pluripotent stem cells from patients and differentiate …

The first priority of a mammalian embryo is to establish an intimate relationship with its
mother. This is accomplished by precocious differentiation of the trophoblast lineage, which …

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological
toxic gain of function. Under physiological conditions, monomeric α-synuclein improves …

The extra-embryonic endoderm lineage plays a major role in the nutritive support of the embryo
and is required for several inductive events, such as anterior patterning and blood island …

Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

… Inoue); Parkinson’s UK Senior Fellowship (F-0902) (T. Kunath); grant-in-aid for scientific
research from the Japan Society for the Promotion of Science (15H04270; H. Ito, 15H05581; AH)…

Protein aggregation and abnormal lipid homeostasis are both implicated in
neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane …

The orphan nuclear receptor ERRβ is expressed in undifferentiated trophoblast stem cell
lines and extraembryonic ectoderm, and genetic ablation of ERRβ results in abnormal …