Large-scale sequence analysis of the AD169 strain of human cytomegalovirus (HCMV)
began in this laboratory in 1984 when very little was known about the sequence or location of …

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been identified …

Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to
external cues to regulate the many uses of DNA. A principle component of chromatin that …

Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl 1 .
Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions …

… Tony Kouzarides … Durocher for advice with SPR, T. Krude for guidance on nuclear
preparations and M. Ruas for preparing some proteins. … Tony Kouzarides …

The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA-…

… Anand and all members of the Huntly and Kouzarides … We thank T. Werner for assistance
with mass spectrometry experiments … This work in the Kouzarides laboratory was funded by a …

THE CBP protein acts as a transcriptional adaptor for many different transcription factors by
directly contacting DNA-bound activators 1–7 . One mechanism by which CBP is thought to …

A recent meeting (December 2008) regarding chromatin-based epigenetics was hosted by
the Banbury Conference Center and Cold Spring Harbor Laboratory. The intent was to …

N 6 -methyladenosine (m 6 A) is an abundant internal RNA modification 1 , 2 that is catalysed
predominantly by the METTL3–METTL14 methyltransferase complex 3 , 4 . The m 6 A …