User profiles for T. Korcsmáros

Tamas Korcsmaros

Imperial College London
Verified email at imperial.ac.uk
Cited by 18828

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome- and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

[HTML][HTML] Network analysis of protein dynamics

…, IA Kovács, MS Szalay, R Palotai, T Korcsmáros… - FEBS letters, 2007 - Elsevier
The network paradigm is increasingly used to describe the topology and dynamics of complex
systems. Here, we review the results of the topological analysis of protein structures as …

How to design multi-target drugs: target search options in cellular networks

T Korcsmáros, MS Szalay, C Böde… - Expert opinion on …, 2007 - Taylor & Francis
Despite improved rational drug design and a remarkable progress in genomic, proteomic and
high-throughput screening methods, the number of novel, single-target drugs has fallen far …

OmniPath: guidelines and gateway for literature-curated signaling pathway resources

D Türei, T Korcsmáros, J Saez-Rodriguez - Nature methods, 2016 - nature.com
Resources that capture information about signaling pathways from the literature are essential
for the experimental design and analysis of many biological studies. Multiple resources are …

[HTML][HTML] SignaLink 2–a signaling pathway resource with multi-layered regulatory networks

…, IJ Farkas, T Vellai, P Csermely, T Korcsmáros - BMC systems …, 2013 - Springer
Background Signaling networks in eukaryotes are made up of upstream and downstream
subnetworks. The upstream subnetwork contains the intertwined network of signaling pathways…

Integrated intra‐and intercellular signaling knowledge for multicellular omics analysis

…, A Gábor, F Theis, D Módos, T Korcsmáros… - Molecular systems …, 2021 - embopress.org
… effect connections from myofibroblasts to regulatory T cells, we created a cell… T cells. We
selected the receptors targeted by condition-specific ligand–receptor connections in regulatory T

Big data in IBD: big progress for clinical practice

…, M Madgwick, P Sudhakar, B Verstockt, T Korcsmaros… - Gut, 2020 - gut.bmj.com
IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and intrinsic
factors, including host genetics, the immune system, environmental factors and the gut …

[HTML][HTML] Endosomal crosstalk: meeting points for signaling pathways

M Pálfy, A Reményi, T Korcsmáros - Trends in cell biology, 2012 - cell.com
Endocytosis participates in downregulating incoming signals, but ‘signaling endosomes' may
also serve as physical platforms for crosstalk between signaling pathways. Here, we briefly …

ComPPI: a cellular compartment-specific database for protein–protein interaction network analysis

…, KZ Szalay, D Fazekas, T Korcsmáros… - Nucleic acids …, 2015 - academic.oup.com
Here we present ComPPI, a cellular compartment-specific database of proteins and their
interactions enabling an extensive, compartmentalized protein–protein interaction network …

[HTML][HTML] The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops

…, R Nussinov, P Csermely, T Korcsmáros - FEBS letters, 2012 - Elsevier
NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress
responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing …