User profiles for T. Hrabe
Thomas HrabeBASF Enzymes Verified email at sbpdiscovery.org Cited by 905 |
[HTML][HTML] Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework
The translation of personal genomics to precision medicine depends on the accurate
interpretation of the multitude of genetic variants observed for each individual. However, even …
interpretation of the multitude of genetic variants observed for each individual. However, even …
PyTom: a python-based toolbox for localization of macromolecules in cryo-electron tomograms and subtomogram analysis
… The annealing ‘temperature’ T controls the acceptance of sub-optimal class assignments.
T is decreased linearly over the annealing iterations. Here, T depends on the standard …
T is decreased linearly over the annealing iterations. Here, T depends on the standard …
[HTML][HTML] A pan-cancer catalogue of cancer driver protein interaction interfaces
… , p t is a vector in which the i-th element holds the probability of being at node i at time t and
… The algorithm iterates the equation until the L 1 norm between p t and p t+1 is less than 10 −…
… The algorithm iterates the equation until the L 1 norm between p t and p t+1 is less than 10 −…
[PDF][PDF] Structure and 3D arrangement of endoplasmic reticulum membrane-associated ribosomes
In eukaryotic cells, cotranslational protein translocation across the endoplasmic reticulum (ER)
membrane requires an elaborate macromolecular machinery. While structural details of …
membrane requires an elaborate macromolecular machinery. While structural details of …
PDBFlex: exploring flexibility in protein structures
The PDBFlex database, available freely and with no login requirements at http://pdbflex.org
, provides information on flexibility of protein structures as revealed by the analysis of …
, provides information on flexibility of protein structures as revealed by the analysis of …
Fast and accurate reference-free alignment of subtomograms
… Use Algorithm 1 to align all the subtomograms against T i . Average all the aligned
subtomograms will result in a new reference T i + 1 , which can be used for the next iteration. …
subtomograms will result in a new reference T i + 1 , which can be used for the next iteration. …
POSA: a user-driven, interactive multiple protein structure alignment server
… Thomas Hrabe , Thomas Hrabe … Zhanwen Li, Padmaja Natarajan, Yuzhen Ye, Thomas
Hrabe, Adam Godzik, POSA: a user-driven, interactive multiple protein structure alignment server, …
Hrabe, Adam Godzik, POSA: a user-driven, interactive multiple protein structure alignment server, …
Cancer3D: understanding cancer mutations through protein structures
The new era of cancer genomics is providing us with extensive knowledge of mutations and
other alterations in cancer. The Cancer3D database at http://www.cancer3d.org gives an …
other alterations in cancer. The Cancer3D database at http://www.cancer3d.org gives an …
[HTML][HTML] ConSole: using modularity of Contact maps to locate Solenoid domains in protein structures
… We use the distance threshold of t = 4.5 Å, following our earlier applications of contact maps
[23], and assign a value of 1 (True) or 0 (False) to each of the N × N positions on the map. As …
[23], and assign a value of 1 (True) or 0 (False) to each of the N × N positions on the map. As …
Detection and identification of macromolecular complexes in cryo-electron tomograms using support vector machines
… Given a tomogram V and the structural template T of the target macromolecular complex,
we … If the candidate is closer than a threshold T, it is labeled as positive, otherwise negative. …
we … If the candidate is closer than a threshold T, it is labeled as positive, otherwise negative. …