Purpose Human epidermal growth factor receptor 2 (HER2, ERBB2)–activating mutations
occur in 2% of lung cancers. We assessed the activity of ado-trastuzumab emtansine, a HER2-…

Approximately 200 BRAF mutant alleles have been identified in human tumours. Activating
BRAF mutants cause feedback inhibition of GTP-bound RAS, are RAS-independent and …

… T. Hembrough reports other from AstraZeneca (employment during this work) during the
conduct of the study and NantOmics (employment during past 36 months) outside the submitted …

Background Concomitant administration of COVID-19 and influenza vaccines could reduce
burden on health-care systems. We aimed to assess the safety of concomitant administration …

The role of KRAS, when activated through canonical mutations, has been well established
in cancer 1 . Here we explore a secondary means of KRAS activation in cancer: focal high-…

… Statistical analysis was performed using the Student t test. … Efficacy was calculated as
above, and results were analyzed for statistical significance using the Student t test. …

Biological therapies such as tumor necrosis factor-α inhibitors have advanced the treatment
of rheumatoid arthritis, but one-third of patients do not respond to such therapy. Furthermore, …

The principles that govern the evolution of tumors exposed to targeted therapy are poorly
understood. Here we modeled the selection and propagation of an amplification in the BRAF …

… Pearson standard correlation values and t test p values are given for each protein differentially
expressed between the no tumour shrinkage and the objective response desmoid tumour …

ENMD-2076 is a novel orally active, small molecule kinase inhibitor with a mechanism of action
involving several pathways key to tumor growth and survival: angiogenesis, proliferation, …