[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …
Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
[HTML][HTML] t4 workshop report: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
…, E Fritsche, A Goldberg, J Hansmann, T Hartung… - Altex, 2014 - ncbi.nlm.nih.gov
Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
CD36 is a sensor of diacylglycerides
… The mutation involves a single base transversion from T to A in the mutant strain, causing
the nonsense substitution Y340#. e, The predicted sequence and graphical display of the …
the nonsense substitution Y340#. e, The predicted sequence and graphical display of the …
Innate immunity in Arabidopsis thaliana: Lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes
… The source of NO was addressed by using T-DNA insertion lines. Interestingly, LPS did not
activate the pathogen-inducible varP NOS, but AtNOS1, a distinct NOS previously associated …
activate the pathogen-inducible varP NOS, but AtNOS1, a distinct NOS previously associated …
[HTML][HTML] Lipoteichoic acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide …
Lipoteichoic acid (LTA) derived fromStreptococcus pneumoniae, purified employing a
chloroform/methanol protocol, and from Staphylococcus aureus, prepared by the recently …
chloroform/methanol protocol, and from Staphylococcus aureus, prepared by the recently …
[HTML][HTML] Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
Many drugs have progressed through preclinical and clinical trials and have been available
– for years in some cases – before being recalled by the FDA for unanticipated toxicity in …
– for years in some cases – before being recalled by the FDA for unanticipated toxicity in …
Toxicology for the twenty-first century
T Hartung - Nature, 2009 - nature.com
… Thomas Hartung … Thomas Hartung is in the Department of Environmental Health
Sciences at the Johns Hopkins University Bloomberg School of Public Health, and is …
Sciences at the Johns Hopkins University Bloomberg School of Public Health, and is …
Structure–Function Relationship of Cytokine Induction by Lipoteichoic Acid fromStaphylococcus aureus
Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory
counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus …
counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus …
One in two cancer patients is significantly distressed: prevalence and indicators of distress
Objective Psychological distress is common in cancer patients, and awareness of its indicators
is essential. We aimed to assess the prevalence of psychological distress and to identify …
is essential. We aimed to assess the prevalence of psychological distress and to identify …