… Its applications were greatly facilitated by the help of Joseph Chou, who developed the
first-generation computer software for dose-effect analysis based on the “mass-action law” (14). …

Since their first observation nearly a decade ago by Iijima (Iijima S. Helical microtubules of
graphitic carbon Nature. 1991; 354:56–8), carbon nanotubes have been the focus of …

… obtained by Yonetani and TheoreU (55) and Chou and Talalay (59) using different methods…
TC CHOU, On the determination of availability of ligand binding sites in steady-state systems…

… More importantly, it is shown that K i /I 50 = E x /E t , where E t is the total amount of enzyme
and E x is the fractional availability of the enzyme species with which the inhibitor may …

The cause of schizophrenia is unknown, but it has a significant genetic component.
Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest …

N 6 -methyladenosine (m 6 A) is an abundant nucleotide modification in mRNA that is
required for the differentiation of mouse embryonic stem cells. However, it remains unknown …

Objective To determine the prevalence and associated mortality of well-defined neurologic
diagnoses among patients with coronavirus disease 2019 (COVID-19), we prospectively …

Ubiquitin-positive, tau- and α-synuclein–negative inclusions are hallmarks of frontotemporal
lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. …

It is possible to use the waveform data not only to derive the source mechanism of an earthquake
but also to establish the hypocentral coordinates of the ‘best point source’ (the centroid …

This paper provides an overview of recent advances in nanocomposites research. The key
research opportunities and challenges in the development of structural and functional …