User profiles for T. Boraud
 | Thomas BoraudCNRS - University of Bordeaux Verified email at u-bordeaux.fr Cited by 9771 |
Neuronal oscillations in the basal ganglia and movement disorders: evidence from whole animal and human recordings
…, JR Walters, R Courtemanche, T Boraud… - Journal of …, 2004 - Soc Neuroscience
… The work presented by Thomas Boraud characterized the evolution of the spontaneous
and movement related activity in the GPi during a slow dopamine depletion induced by daily …
and movement related activity in the GPi during a slow dopamine depletion induced by daily …
Low statistical power in biomedical science: a review of three human research domains
Studies with low statistical power increase the likelihood that a statistically significant finding
represents a false positive result. We conducted a review of meta-analyses of studies …
represents a false positive result. We conducted a review of meta-analyses of studies …
From single extracellular unit recording in experimental and human Parkinsonism to the development of a functional concept of the role played by the basal ganglia in …
Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects the
whole basal ganglia (BG). Various techniques have been used to study BG physiology and …
whole basal ganglia (BG). Various techniques have been used to study BG physiology and …
Reversal of rigidity and improvement in motor performance by subthalamic high‐frequency stimulation in MPTP‐treated monkeys
…, C Gross, J Féger, T Boraud… - European Journal of …, 1993 - Wiley Online Library
In Parkinson's disease the loss of dopaminergic neurons in the substantia nigra is associated
with global disorganization of basal ganglia activity and, in particular, with increased …
with global disorganization of basal ganglia activity and, in particular, with increased …
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
In monkeys rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),
expression of the dopamine D 3 receptor was decreased. However, levodopa-induced …
expression of the dopamine D 3 receptor was decreased. However, levodopa-induced …
Subthalamic high frequency stimulation resets subthalamic firing and reduces abnormal oscillations
… The filtered analogue signal of each example is superimposed to a peristimulus histogram
of the respective STN neuron that is aligned to the onset of the stimulation artefact (t = 0 ms) in …
of the respective STN neuron that is aligned to the onset of the stimulation artefact (t = 0 ms) in …
Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia
… For simplicity, we take T iα = T α independently of i for α = Ctx, GPi, Th, STN. In contrast,
we take a broad Gaussian distribution for the thresholds of the striatal neurons (average, …
we take a broad Gaussian distribution for the thresholds of the striatal neurons (average, …
High frequency stimulation of the internal Globus Pallidus (GPi) simultaneously improves parkinsonian symptoms and reduces the firing frequency of GPi neurons in …
… Mean firing frequency was significantly different from that of the neurons recorded after
treatment with MPTP (t-test; P<0.001) and not significantly different from that of normal animals (t-…
treatment with MPTP (t-test; P<0.001) and not significantly different from that of normal animals (t-…
Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study
A Benazzouz, T Boraud, P Dubédat, A Boireau… - European journal of …, 1995 - Elsevier
… The peak amplitude (PA) and surface area (S) of the EMG burst activity were studied for
biceps and triceps muscles and Student's t-test was used to objectivate a significant difference …
biceps and triceps muscles and Student's t-test was used to objectivate a significant difference …
Electrophysiological and metabolic evidence that high‐frequency stimulation of the subthalamic nucleus bridles neuronal activity in the subthalamic nucleus and the …
HIGH‐FREQUENCY STIMULATION (HFS) of the subthalamic nucleus (STN) has been
shown to produce a dramatic alleviation of motor symptoms in patients with advanced …
shown to produce a dramatic alleviation of motor symptoms in patients with advanced …