Sepsis, an infection-induced inflammatory syndrome, is a leading and increasing cause of
mortality worldwide. Animal and human observational studies suggest statins may prevent the …

With the proportion of elderly people increasing in many countries, osteoporosis has become
a growing public health problem, with rising medical, social, and economic consequences. …

The Alzheimer's disease β-amyloid peptide (Aβ) is produced by excision from the type 1
integral membrane glycoprotein amyloid precursor protein (APP) by the sequential actions of β- …

The canonical molecular machinery required for global mRNA translation and its control
has been well defined, with distinct sets of proteins involved in the processes of translation …

A three-dimensional extension of two-dimensional digital image correlation has been
developed. The technique uses digital image volumes generated through high-resolution X-ray …

The dopaminergic neurotoxin N-methyl,4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) causes
a syndrome in primates and humans which mimics Parkinson's disease (PD) in clinical, …

Aim Our main goals were to develop a map of the life zones for the conterminous United
States, based on the Holdridge Life Zone system, as a tool for ecosystem mapping, and to …

Class I phosphoinositide-3-kinase (PI3K) isoforms generate the intracellular signaling lipid,
phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P 3 ). PtdIns(3,4,5)P 3 regulates major …

Objective: Anemia and operative blood loss are common in the elderly, but evidence is lacking
on whether intraoperative blood transfusions can reduce the risk of postoperative death. …

Ubiquitination regulates the stability and/or activity of numerous cellular proteins. The corollary
is that de-ubiquitinating enzymes, which ‘trim’ polyubiquitin chains from specific substrate …