Acute postoperative pain is followed by persistent pain in 10–50% of individuals after common
operations, such as groin hernia repair, breast and thoracic surgery, leg amputation, and …

Background New drug treatments, clinical trials, and standards of quality for assessment of
evidence justify an update of evidence-based recommendations for the pharmacological …

Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical
recommendations for pharmacologic management are needed. Systematic literature …

Pain usually results from activation of nociceptive afferents by actually or potentially tissue-damaging
stimuli. Pain may also arise by activity generated within the nervous system without …

Background and objectives: This second European Federation of Neurological Societies
Task Force aimed at updating the existing evidence about the pharmacological treatment of …

Neuropathic pain treatment remains unsatisfactory despite a substantial increase in the
number of trials. This EFNS Task Force aimed at evaluating the existing evidence about the …

Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are
tightly regulated at defined stages of the cell division cycle. Progression through this cycle …

New studies of the treatment of neuropathic pain have increased the need for an updated
review of randomized, double-blind, placebo-controlled trials to support an evidence based …

Tricyclic antidepressants and carbamazepine have become the mainstay in the treatment of
neuropathic pain. Within the last decade, controlled trials have shown that numerous other …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are in …