Dynamic molecular interactions play a central role in regulating the functioning of cells and
organisms. The availability of experimentally determined large-scale cellular networks, along …

Cancer cells accumulate many genetic alterations throughout their lifetime, but only a few of
them drive cancer progression, termed driver mutations. Driver mutations may vary between …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

The centrality-lethality rule, which notes that high-degree nodes in a protein interaction
network tend to correspond to proteins that are essential, suggests that the topological …

Background Personalized, precision, P4, or stratified medicine is understood as a medical
approach in which patients are stratified based on their disease subtype, risk, prognosis, or …

… The first approach to use a patient network to infer genotype–phenotype relationships was
proposed by Cho and Przytycka [7]. By combining a patient similarity network and a topic …

DNase I hypersensitive sites (DHSs) provide important information on the presence of
transcriptional regulatory elements and the state of chromatin in mammalian cells 1 , 2 , 3 . …

Complex diseases are caused by a combination of genetic and environmental factors.
Uncovering the molecular pathways through which genetic factors affect a phenotype is always …

Transcription has the capacity to mechanically modify DNA topology, DNA structure and
nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn may …

We report a mechanism through which the transcription machinery directly controls
topoisomerase 1 (TOP1) activity to adjust DNA topology throughout the transcription cycle. By …