User profiles for T. M. Hyde
Thomas M. HydeChief Operating Officer, Lieber Institute for Brain Development Verified email at libd.org Cited by 33489 |
Psychiatric disturbances in metachromatic leukodystrophy: insights into the neurobiology of psychosis
TM Hyde, JC Ziegler, DR Weinberger - Archives of neurology, 1992 - jamanetwork.com
• Metachromatic leukodystrophy is a rare inherited disorder of the nervous system. Symptoms
initially can present during childhood, adolescence, or adulthood. Psychiatric symptoms, …
initially can present during childhood, adolescence, or adulthood. Psychiatric symptoms, …
Course of schizophrenia: neuropsychological evidence for a static encephalopathy
TE Goldberg, TM Hyde, JE Kleinman… - Schizophrenia …, 1993 - academic.oup.com
The course of cognitive function in schizophrenia has often been debated. In one view, it is
thought to be akin to that of a progressive dementia with relentless cognitive decline. In …
thought to be akin to that of a progressive dementia with relentless cognitive decline. In …
Myelin, myelin-related disorders, and psychosis
The neuropathological basis of schizophrenia and related psychoses remains elusive despite
intensive scientific investigation. Symptoms of psychosis have been reported in a number …
intensive scientific investigation. Symptoms of psychosis have been reported in a number …
Spatio-temporal transcriptome of the human brain
Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the human …
However, our understanding of the complexity and dynamics of the transcriptome of the human …
[PDF][PDF] Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
…, S Melhem, BS Kolachana, TM Hyde… - The American Journal of …, 2004 - cell.com
Catechol-O-methyltransferase (COMT) is a key enzyme in the elimination of dopamine in the
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …
prefrontal cortex of the human brain. Genetic variation in the COMT gene (MIM 116790) has …
Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia
CS Weickert, TM Hyde, BK Lipska, MM Herman… - Molecular …, 2003 - nature.com
Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal
cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic …
cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic …
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Previous investigations have combined transcriptional and genetic analyses in human cell
lines 1 , 2 , 3 , but few have applied these techniques to human neural tissue 4 , 5 , 6 , 7 , 8 . …
lines 1 , 2 , 3 , but few have applied these techniques to human neural tissue 4 , 5 , 6 , 7 , 8 . …
[PDF][PDF] Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons
Recent advances in 3D culture systems have led to the generation of brain organoids that
resemble different human brain regions; however, a 3D organoid model of the midbrain …
resemble different human brain regions; however, a 3D organoid model of the midbrain …
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …
us uniquely human. The development of the brain is a highly complex process, and this …
Dopaminergic modulation of cortical function in patients with Parkinson's disease
…, TE Goldberg, TN Chase, TM Hyde… - Annals of Neurology …, 2002 - Wiley Online Library
Patients with idiopathic Parkinson's disease suffer not only from classic motor symptoms, but
from deficits in cognitive function, primarily those subserved by the prefrontal cortex as well. …
from deficits in cognitive function, primarily those subserved by the prefrontal cortex as well. …