The central role of protein kinases in signal transduction pathways has generated intense
interest in targeting these enzymes for a wide range of therapeutic indications. Here we report …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset
autosomal dominant Parkinson's disease. We employed a new, parallel, compound-centric …

The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce
and integrate extracellular stimuli into coordinated cellular response. Here, we report the …

Protein kinases are intensely studied mediators of cellular signaling, yet important
questions remain regarding their regulation and in vivo properties. Here, we use a probe-based …

The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the
integral membrane enzyme fatty acid amide hydrolase (FAAH). Pharmacological blockade …

Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty
acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic …

Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades
the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. …

The Rho GDP-dissociation inhibitors (GDIs) negatively regulate Rho-family GTPases 1 , 2 .
The inhibitory activity of GDI derives both from an ability to bind the carboxy-terminal …

Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with
transcriptional activation capability in addition to an N-terminal canonical kinase domain. …

The GDP-dissociation-inhibitor (GDI) for Rho-like GTP-binding proteins is capable of three
different biochemical activities. These are the inhibition of GDP dissociation, the inhibition of …