Pax6 is a transcription factor essential for the development of tissues including the eyes,
central nervous system and endocrine glands of vertebrates and invertebrates. It regulates the …

mRNA translation, or protein synthesis, is a major component of the transformation of the
genetic code into any cellular activity. This complicated, multistep process is divided into three …

The influence that neurons exert on astrocytic function is poorly understood. To investigate
this, we first developed a system combining cortical neurons and astrocytes from closely …

Pax6 is a developmental control gene with an essential role in development of the eye, brain
and pancreas. Pax6, as many other developmental regulators, depends on a substantial …

Levels of expression of the transcription factor Pax6 vary throughout corticogenesis in a
rostro-lateral high to caudo-medial low gradient across the cortical proliferative zone. Previous …

The mechanisms by which early spatiotemporal expression patterns of transcription factors
such as Pax6 regulate cortical progenitors in a region-specific manner are poorly understood…

The invasive behaviour of tumour cells has been attributed in part to dysregulated cell
motility. Members of the ADF/Cofilin family of actin‐binding proteins are known to increase …

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by
selective loss of motor neurons, muscle atrophy and paralysis. Mutations in the human VAMP-…

Genes encoding synaptic proteins are highly associated with neuronal disorders many of
which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that …

In neurogenesis, neural cell fate specification is generally triggered by proneural transcription
factors. Whilst the role of proneural factors in fate specification is well studied, the link …