The evolution of parasitism is a recurrent event in the history of life and a core problem in
evolutionary biology. Trypanosomatids are important parasites and include the human …

Background Next generation sequencing (NGS) technology has revolutionized genomic and
genetic research. The pace of change in this area is rapid with three major new sequencing …

The assembly of DNA sequence data is undergoing a renaissance thanks to emerging
technologies capable of producing reads tens of kilobases long. Assembling complete bacterial …

Background The process of generating raw genome sequence data continues to become
cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished …

INTRODUCTION Malaria remains a devastating global parasitic disease, with the majority
of malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, …

Due to the availability of new sequencing technologies, we are now increasingly interested
in sequencing closely related strains of existing finished genomes. Recently a number of de …

Background . Malaria in humans is caused by apicomplexan parasites belonging to 5 species
of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but …

Leishmania parasites cause a spectrum of clinical pathology in humans ranging from
disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference …

Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people
in developing countries. Amongst the human-infective species, Schistosoma mansoni is also …