As a first step toward understanding how rare variants contribute to risk for complex diseases,
we sequenced 15,585 human protein-coding genes to an average median depth of 111× …

Establishing the age of each mutation segregating in contemporary human populations is
important to fully understand our evolutionary history 1 , 2 and will help to facilitate the …

Most great ape genetic variation remains uncharacterized 1 , 2 ; however, its study is critical
for understanding population history 3 , 4 , 5 , 6 , recombination 7 , selection 8 and …

Gorillas are humans’ closest living relatives after chimpanzees, and are of comparable
importance for the study of human origins and evolution. Here we present the assembly and …

To assess the relationship between central control of upper airway and respiratory muscle,
simultaneously recorded diaphragmatic electromyogram (EMGdi) and genioglossal EMG (…

The African Diaspora in the Western Hemisphere represents one of the largest forced
migrations in history and had a profound impact on genetic diversity in modern populations. To …

Human diets in developed countries such as the US have changed dramatically over the
past 75 years, leading to gene by diet interactions that have altered intermediate molecular …

Native Americans from the Amazon, Andes, and coastal geographic regions of South America
have a rich cultural heritage but are genetically understudied, therefore leading to gaps in …

Intellectual disability (ID) is a clinically and genetically heterogeneous disorder, affecting 1–3%
of the general population. Although research into the genetic causes of ID has recently …

Mucormycosis is a life-threatening infection caused by Mucorales fungi. Here we sequence
30 fungal genomes, and perform transcriptomics with three representative Rhizopus and …