The importance of the Gallus gallus (chicken) as a model organism and agricultural animal
merits a continuation of sequence assembly improvement efforts. We present a new version …

IFN regulatory factor 6 (IRF6) is a transcription factor that, in mammals, is required for the
differentiation of skin, breast epithelium, and oral epithelium. However, the transcriptional …

Genome editing followed by reproductive cloning was previously used to produce two hornless
dairy bulls. We crossed one genome-edited dairy bull, homozygous for the dominant P C …

Despite significant healthcare advances in the 21st century, the exact etiology of dental
caries remains unsolved. The past two decades have witnessed a tremendous growth in our …

Domestic dog breeds exhibit remarkable morphological variations that result from centuries
of artificial selection and breeding. Identifying the genetic changes that contribute to these …

Mutations in IRF6, TFAP2A and GRHL3 cause orofacial clefting syndromes in humans.
However, Tfap2a and Grhl3 are also required for neurulation in mice. Here, we found that …

Background The homologous recombination (HR) pathway is largely inactive in early embryos
prior to the first cell division, making it difficult to achieve targeted gene knock-ins. The …

Background The etiology of dental caries remains poorly understood. With the advent of next-generation
sequencing, a number of studies have focused on the microbial ecology of the …

This paper investigates the appearance and the mechanical properties of the friction stir
welded plates with different parameters. The induced heat during the welding process plays the …

Background Transcriptome interpretation relies on a good-quality reference transcriptome for
accurate quantification of gene expression as well as functional analysis of genetic variants…