Our recent studies of plasma, fibroblasts, transfected cells and transgenic mice show that a
fundamental effect of the mutations linked to familial Alzheimer's disease (FAD) is to increase …

Prior to the identification of the various abnormal proteins deposited as fibrillar aggregates in
the Alzheimer’s disease (AD) brain, there was tremendous controversy over the importance …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

To determine whether the presenilin 1 (PS1), presenilin 2 (PS2) and amyloid β-protein precursor
(APP) mutations linked to familial Alzheimer's disease (FAD) increase the extracellular …

… in which they swam for 60 s with the platform removed. Two- … s with the platform removed
(20). One measure of the animals' knowledge of platform location is the percentage of the 60-s …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…

… The number of thioflavin S-positive deposits consistently … for thioflavin S and Congo red
and r = 0.81 for thioflavin S and Aß … The higher absolute values for thioflavin S indicate that the …

Background Homozygous loss-of-function mutations in TREM2, encoding the triggering
receptor expressed on myeloid cells 2 protein, have previously been associated with an …