Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications
The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …
and development more difficult. Various approaches have been developed with a focus on …
Influenza virus receptors in the human airway
K Shinya, M Ebina, S Yamada, M Ono, N Kasai… - Nature, 2006 - nature.com
Although more than 100 people have been infected by H5N1 influenza A viruses, human-to-human
transmission is rare 1 . What are the molecular barriers limiting human-to-human …
transmission is rare 1 . What are the molecular barriers limiting human-to-human …
Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis
K Kodama, D Tojjar, S Yamada, K Toda… - Diabetes …, 2013 - Am Diabetes Assoc
… Two studies (12,13) have reported that S I measured by the … no significant difference between
S I (insulin) and S I (regular) … values of S I (tolbutamide) to the approximate estimates of S I (…
S I (insulin) and S I (regular) … values of S I (tolbutamide) to the approximate estimates of S I (…
Evidence for oscillation of atmospheric neutrinos
…, Y Suzuki, Y Takeuchi, Y Totsuka, S Yamada… - Physical review …, 1998 - APS
We present an analysis of atmospheric neutrino data from a 33.0 kton yr (535-day) exposure
of the Super-Kamiokande detector. The data exhibit a zenith angle dependent deficit of …
of the Super-Kamiokande detector. The data exhibit a zenith angle dependent deficit of …
Solar and hep Neutrino Measurements from 1258 Days of Super-Kamiokande Data
…, Y Takeuchi, T Toshito, Y Totsuka, S Yamada, S Desai… - Physical review …, 2001 - APS
Solar neutrino measurements from 1258 days of data from the Super-Kamiokande detector
are presented. The measurements are based on recoil electrons in the energy range 5.0–…
are presented. The measurements are based on recoil electrons in the energy range 5.0–…
Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
…, NJ Cox, Y Oda, H Yano, MM Le Beau, S Yamada… - Nature, 1996 - nature.com
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
S Yamada, Y Suzuki, T Suzuki, MQ Le, CA Nidom… - Nature, 2006 - nature.com
H5N1 influenza A viruses have spread to numerous countries in Asia, Europe and Africa,
infecting not only large numbers of poultry, but also an increasing number of humans, often …
infecting not only large numbers of poultry, but also an increasing number of humans, often …
Indications of neutrino oscillation in a 250 km long-baseline experiment
…, CW Walter, RJ Wilkes, S Yamada, S Yamamoto… - Physical Review Letters, 2003 - APS
The K2K experiment observes indications of neutrino oscillation: a reduction of ν μ flux together
with a distortion of the energy spectrum. Fifty-six beam neutrino events are observed in …
with a distortion of the energy spectrum. Fifty-six beam neutrino events are observed in …
Measurement of the flux and zenith-angle distribution of upward throughgoing muons by Super-Kamiokande
…, Y Suzuki, Y Takeuchi, Y Totsuka, S Yamada… - Physical review …, 1999 - APS
A total of 614 upward throughgoing muons of minimum energy 1.6 GeV are observed by
Super-Kamiokande during 537 detector live days. The measured muon flux is [1.74±0.07 (stat)±…
Super-Kamiokande during 537 detector live days. The measured muon flux is [1.74±0.07 (stat)±…
[HTML][HTML] Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
M Muramatsu, K Kinoshita, S Fagarasan, S Yamada… - Cell, 2000 - cell.com
… The Ig C H locus consists of the ordered array of C H genes, each flanked at its 5′
region by an S region which is composed of tandem repetitive unit sequences with many …
region by an S region which is composed of tandem repetitive unit sequences with many …