Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications

…, K Wada, M Nakatani, S Yamada, S Onoue - International journal of …, 2011 - Elsevier
The poor oral bioavailability arising from poor aqueous solubility should make drug research
and development more difficult. Various approaches have been developed with a focus on …

Influenza virus receptors in the human airway

K Shinya, M Ebina, S Yamada, M Ono, N Kasai… - Nature, 2006 - nature.com
Although more than 100 people have been infected by H5N1 influenza A viruses, human-to-human
transmission is rare 1 . What are the molecular barriers limiting human-to-human …

Ethnic differences in the relationship between insulin sensitivity and insulin response: a systematic review and meta-analysis

K Kodama, D Tojjar, S Yamada, K Toda… - Diabetes …, 2013 - Am Diabetes Assoc
… Two studies (12,13) have reported that S I measured by the … no significant difference between
S I (insulin) and S I (regular) … values of S I (tolbutamide) to the approximate estimates of S I (…

Evidence for oscillation of atmospheric neutrinos

…, Y Suzuki, Y Takeuchi, Y Totsuka, S Yamada… - Physical review …, 1998 - APS
We present an analysis of atmospheric neutrino data from a 33.0 kton yr (535-day) exposure
of the Super-Kamiokande detector. The data exhibit a zenith angle dependent deficit of …

Solar and hep Neutrino Measurements from 1258 Days of Super-Kamiokande Data

…, Y Takeuchi, T Toshito, Y Totsuka, S Yamada, S Desai… - Physical review …, 2001 - APS
Solar neutrino measurements from 1258 days of data from the Super-Kamiokande detector
are presented. The measurements are based on recoil electrons in the energy range 5.0–…

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

…, NJ Cox, Y Oda, H Yano, MM Le Beau, S Yamada… - Nature, 1996 - nature.com
THE disease non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is characterized by
abnormally high blood glucose resulting from a relative deficiency of insulin 1 . It affects …

Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

S Yamada, Y Suzuki, T Suzuki, MQ Le, CA Nidom… - Nature, 2006 - nature.com
H5N1 influenza A viruses have spread to numerous countries in Asia, Europe and Africa,
infecting not only large numbers of poultry, but also an increasing number of humans, often …

Indications of neutrino oscillation in a 250 km long-baseline experiment

…, CW Walter, RJ Wilkes, S Yamada, S Yamamoto… - Physical Review Letters, 2003 - APS
The K2K experiment observes indications of neutrino oscillation: a reduction of ν μ flux together
with a distortion of the energy spectrum. Fifty-six beam neutrino events are observed in …

Measurement of the flux and zenith-angle distribution of upward throughgoing muons by Super-Kamiokande

…, Y Suzuki, Y Takeuchi, Y Totsuka, S Yamada… - Physical review …, 1999 - APS
A total of 614 upward throughgoing muons of minimum energy 1.6 GeV are observed by
Super-Kamiokande during 537 detector live days. The measured muon flux is [1.74±0.07 (stat)±…

[HTML][HTML] Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

M Muramatsu, K Kinoshita, S Fagarasan, S Yamada… - Cell, 2000 - cell.com
… The Ig C H locus consists of the ordered array of C H genes, each flanked at its 5′
region by an S region which is composed of tandem repetitive unit sequences with many …