While sequencing of the human genome surprised us with how many protein-coding genes
there are, it did not fundamentally change our perspective on what a gene is. In contrast, the …

Recent research on disparate psychiatric disorders has implicated rare variants in genes
involved in global gene regulation and chromatin modification, as well as many common …

Publisher Summary This chapter summarizes the current knowledge about the structure–function
relationships of the globin gene system as derived from studies at the level of DNA and …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT)
was identified by positional cloning on chromosome 11q22-23. AT is characterized by …

The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

… We derived nonlinear, combinatorial models of each focus-factor’s co-binding map relative
to randomized control maps (Supplementary Information, section C.2, and Supplementary Fig…

Intramolecular Energy Transfer Page 1 214 SI WEISSMAN cial refining process the variation
in the crystallization factor with time rate of cooling may not be of great importance. The …

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many
organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here…