Previously published guidelines for the diagnosis and management of primary immune
thrombocytopenia (ITP) require updating largely due to the introduction of new classes of …

… The posterior lobe of the pituitary contains dynorphins and neo-endorphins in the same
processes that release vasopressin (Watson et aI1982a). Whether these opioids potentiate or …

There is a wide body of evidence to suggest the existence of at least three distinct opioid
receptor types in the CNS, referred to as~, 6, and K. This paper reviews some of the findings …

Background Before 2020, mental disorders were leading causes of the global health-related
burden, with depressive and anxiety disorders being leading contributors to this burden. …

Background Mortality statistics are fundamental to public health decision making. Mortality
varies by time and location, and its measurement is affected by well known biases that have …

Animal experiments remain essential to understand the fundamental mechanisms underpinning
malignancy and to discover improved methods to prevent, diagnose and treat cancer. …

Researchers commonly report that families of children with autism spectrum disorder (ASD)
experience more parenting stress than families of typically developing (TD) children or those …

… Einstein started fromhis 1907model for the atomic vibrations of a solid as harmonic oscillators,
all vibrating at the same frequency v.~s If the oscillators are not coupled to one another, …

Genome-wide expression profiling is a powerful tool for implicating novel gene ensembles
in cellular mechanisms of health and disease. The most popular platform for genome-wide …

Background In September 2012, the World Health Organization reported the first cases of
pneumonia caused by the novel Middle East respiratory syndrome coronavirus (MERS-CoV). …