… by a weighted linear function of some other variable(s). This is a perfectly legitimate model,
… Given this, I argue that one should identify their loss function(s) and then decide whether …

… In equation (2), θ k denotes the template switch probability between markers k and k+1 (analogous
to a recombination fraction), S k+1 is the genotype in the study sample, P(S k+1 |Y i ) …

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50%
of phenotypic variation in human height, but identifying the specific variants and …

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

This review examines the current state of electrophysiological endophenotype research and
recommends best practices that are based on knowledge gleaned from the last decade of …

… In the absence of heterogeneity, it is expected that a given SNP’s GWAS effects on the input
phenotypes will scale proportionally to the factor loadings 24 (Supplementary Methods). The …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

… This was the only study that included two disease outcomes, and we treated the Alzheimer’s
results return separately from the Alzheimer’s–cardiovascular combined results return. Note …

… Narrow-sense heritability, h 2 , the proportion of a trait’s phenotypic variance attributable
to additive genetic variance, is a fundamental concept in quantitative genetics. In addition to …