[HTML][HTML] Inflammasome activation at the crux of severe COVID-19
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
results in life-threatening disease in a minority of patients, especially elderly …
results in life-threatening disease in a minority of patients, especially elderly …
Multicenter interim guidance on use of antivirals for children with coronavirus disease 2019/severe acute respiratory syndrome coronavirus 2
Background Although coronavirus disease 2019 (COVID-19) is a mild infection in most
children, a small proportion develop severe or critical illness. Data describing agents with …
children, a small proportion develop severe or critical illness. Data describing agents with …
Consensus treatment plans for chronic nonbacterial osteomyelitis refractory to nonsteroidal antiinflammatory drugs and/or with active spinal lesions
…, AM Cooper, ML Basiaga, SS Vora… - Arthritis Care & …, 2018 - Wiley Online Library
Objective To develop standardized treatment regimens for chronic nonbacterial osteomyelitis
(CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), to enable …
(CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO), to enable …
nuscenes: A multimodal dataset for autonomous driving
… According to our evaluation protocol (Section 3.1), one is only allowed to use 0.5s of previous
data to make a detection decision. This corresponds to 10 previous lidar sweeps since the …
data to make a detection decision. This corresponds to 10 previous lidar sweeps since the …
Pointpillars: Fast encoders for object detection from point clouds
Object detection in point clouds is an important aspect of many robotics applications such as
autonomous driving. In this paper, we consider the problem of encoding a point cloud into a …
autonomous driving. In this paper, we consider the problem of encoding a point cloud into a …
Highly efficient Cas9-mediated transcriptional programming
The RNA-guided nuclease Cas9 can be reengineered as a programmable transcription
factor. However, modest levels of gene activation have limited potential applications. We …
factor. However, modest levels of gene activation have limited potential applications. We …
[HTML][HTML] FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
…, M Lewandrowski, J Ingber, B Parry, S Ravid, S Clark… - Nature, 2022 - nature.com
… With the cycling conditions used (30 s at 95 C; then 40 cycles of 30 s at 95 C, 30 s at 60 C
and 90 s at 72 C), full-length gRNA was not amplified, but small sgRNA segments (<3 kb) …
and 90 s at 72 C), full-length gRNA was not amplified, but small sgRNA segments (<3 kb) …
Gasdermin D pore structure reveals preferential release of mature interleukin-1
As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …
Pointpainting: Sequential fusion for 3d object detection
… The painted version of PointRCNN represents a new state of the art on the KITTI leaderboard
for the bird’s-eye view detection task. In ablation, we study how the effects of Painting …
for the bird’s-eye view detection task. In ablation, we study how the effects of Painting …
[HTML][HTML] BRAF–MEK inhibition in newly diagnosed papillary craniopharyngiomas
…, P Kumthekar, B Mann, S Vora… - … England Journal of …, 2023 - Mass Medical Soc
Background Craniopharyngiomas, primary brain tumors of the pituitary–hypothalamic axis,
can cause clinically significant sequelae. Treatment with the use of surgery, radiation, or both …
can cause clinically significant sequelae. Treatment with the use of surgery, radiation, or both …