Analysis of shared heritability in common disorders of the brain
…, B Penninx, V Artto, M Kaunisto, S Vepsäläinen… - Science, 2018 - science.org
… Alzheimer’s disease, Parkinson’s disease, and MS … ’s disease, nor did we observe enrichment
for immune-related tissues in the functional partitioning (fig. S7) as observed for Crohn’s …
for immune-related tissues in the functional partitioning (fig. S7) as observed for Crohn’s …
APOE and Alzheimer disease: a major gene with semi-dominant inheritance
…, S Sorbi, G Spalletta, F Valdivieso, S Vepsäläinen… - Molecular …, 2011 - nature.com
… To estimate the values of S i,g,s … S i,s the probability for an individual of sex s of surviving
over the age category i that spans from age t 1 to age t 2 , then we can derive S i,g,s from S i,s …
over the age category i that spans from age t 1 to age t 2 , then we can derive S i,g,s from S i,s …
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
…, M Färkkilä, V Artto, M Kaunisto, S Vepsäläinen… - Nature …, 2016 - nature.com
Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …
but its molecular mechanisms remain poorly understood. There is some debate about …
Role of α-synuclein in presynaptic dopamine recruitment
L Yavich, H Tanila, S Vepsäläinen… - Journal of …, 2004 - Soc Neuroscience
… 1a, arrowheads) reflect the amount of dopamine available for immediate release after a
depletion induced by previous burst(s). Taking peak dopamine release after the very first …
depletion induced by previous burst(s). Taking peak dopamine release after the very first …
Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease
…, S Helisalmi, A Mannermaa, S Vepsalainen… - Neurology, 2004 - AAN Enterprises
Background: Brain aromatase may be neuroprotective by increasing the local estrogen
levels in injured neurons. Aromatase is encoded by the CYP19 gene located at 15q21.1, a …
levels in injured neurons. Aromatase is encoded by the CYP19 gene located at 15q21.1, a …
Training the brain to weight speech cues differently: A study of Finnish second-language users of English
Foreign-language learning is a prime example of a task that entails perceptual learning.
The correct comprehension of foreign-language speech requires the correct recognition of …
The correct comprehension of foreign-language speech requires the correct recognition of …
Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse …
S Vepsäläinen, H Koivisto, E Pekkarinen… - The Journal of nutritional …, 2013 - Elsevier
… Once the mouse had returned to its side of the cage, a 15-s … In the testing phase (Days
1–4), five 60-s trials/day were … platform within 60 s, it was placed on the platform for 10 s by the …
1–4), five 60-s trials/day were … platform within 60 s, it was placed on the platform for 10 s by the …
[PDF][PDF] Common variant burden contributes to the familial aggregation of migraine in 1,589 families
…, MA Kaunisto, E Hämäläinen, S Vepsäläinen… - Neuron, 2018 - cell.com
Complex traits, including migraine, often aggregate in families, but the underlying genetic
architecture behind this is not well understood. The aggregation could be explained by rare, …
architecture behind this is not well understood. The aggregation could be explained by rare, …
Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease
S Vepsäläinen, E Castren, S Helisalmi, S Iivonen… - Journal of …, 2005 - Springer
According to previous biochemical and genetic findings, brain–derived neurotrophic factor (BDNF),
via activation of its tyrosine kinase receptor B (TrkB), is considered as a plausible …
via activation of its tyrosine kinase receptor B (TrkB), is considered as a plausible …
Combined risk effects of IDE and NEP gene variants on Alzheimer disease
S Vepsäläinen, S Helisalmi, A Mannermaa… - Journal of Neurology …, 2009 - jnnp.bmj.com
Polymorphisms in genes encoding amyloid β-peptide (Aβ)-degrading enzymes neprilysin (NEP)
and insulin-degrading enzyme (IDE) individually affect the susceptibility to Alzheimer …
and insulin-degrading enzyme (IDE) individually affect the susceptibility to Alzheimer …