Biological insights from 108 schizophrenia-associated genetic loci

…, E Söderman, S Thirumalai, D Toncheva, S Tosato… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

…, K Choudhury, S Datta, J Pimm, S Thirumalai… - Nature, 2009 - nature.com
… (V S ) will be further attenuated by sampling variation and P T threshold, such that V S ≤ V
… , by identifying models that produced profiles of V S across P T threshold that were similar to …

Complement genes contribute sex-biased vulnerability in diverse disorders

…, S Thirumalai, D Toncheva, PA Tooney, S Tosato… - Nature, 2020 - nature.com
… risk for SLE and Sjögren’s syndrome. In all three illnesses, … -fold variation in risk for Sjögren’s
syndrome, and 1.7-fold variation … ’s greater risk of SLE and Sjögren’s syndrome and men’s

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

…, DM Svrakic, JP Szatkiewicz, S Thirumalai… - Nature …, 2016 - nature.com
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …

Product recalls in the medical device industry: An empirical exploration of the sources and financial consequences

S Thirumalai, KK Sinha - Management Science, 2011 - pubsonline.informs.org
Medical devices play an increasingly significant role in the delivery of health care today.
However, persistent quality problems with medical devices and the associated recalls present …

Customer satisfaction with order fulfillment in retail supply chains: implications of product type in electronic B2C transactions

S Thirumalai, KK Sinha - Journal of Operations Management, 2005 - Elsevier
This paper focuses on the proverbial “last mile” of the retail supply chain – ie, delivering
products to the end-customer – and highlights the need for recognizing product type differences …

Customization of the online purchase process in electronic retailing and customer satisfaction: An online field study

S Thirumalai, KK Sinha - Journal of operations management, 2011 - Elsevier
This paper investigates the customization of the online purchase process in electronic
retailing. We conceptualize customization relevant to the two constituent sub-processes in the …

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder

…, K Suominen, J Suvisaari, S Thirumalai… - Molecular …, 2009 - nature.com
Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia,
schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but …

Rapid eye movement sleep behavior disorder in children with autism

SS Thirumalai, RA Shubin… - Journal of child …, 2002 - journals.sagepub.com
We performed nocturnal polysomnography on 11 children with autism who had symptoms of
disrupted sleep and nocturnal awakenings. We identified rapid eye movement (REM) sleep …

Case–case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes

…, V Puri, R Krasucki, J Pimm, S Thirumalai… - Psychiatric …, 2011 - journals.lww.com
Objective There are theoretical reasons why comparing marker allele frequencies between
cases of different diseases, rather than with controls, may offer benefits. The samples may be …