User profiles for S. Sundararaman

Swaminathan Sundararaman

- Verified email at cs.wisc.edu - Cited by 4596

Sesh Sundararaman

- Verified email at EMAIL.CHOP.EDU - Cited by 1342

Shriram K. Sundararaman

- Verified email at bidmc.harvard.edu - Cited by 545

[HTML][HTML] Out of Africa: origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax

…, GH Learn, LJ Plenderleith, SA Sundararaman… - International journal for …, 2017 - Elsevier
… Although the mechanism(s) that maintain the dimorphic msp alleles in P. falciparum
remain largely unknown (Roy and Ferreira, 2015), some genes appear to be under balancing …

[HTML][HTML] PCSK9: A multi-faceted protein that is involved in cardiovascular biology

SS Sundararaman, Y Döring, EPC van Der Vorst - Biomedicines, 2021 - mdpi.com
Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells. …

Suppression of STING associated with LKB1 loss in KRAS-driven lung cancer

…, S Guo, R Yoshida, M Campisi, SK Sundararaman… - Cancer discovery, 2019 - AACR
… This effect is mediated at least in part by hyperactivation of DNMT1 and EZH2 activity
related to elevated S-adenylmethionine levels and reinforced by DNMT1 upregulation. Ectopic …

[HTML][HTML] African origin of the malaria parasite Plasmodium vivax

…, JA Malenke, SA Sundararaman… - Nature …, 2014 - nature.com
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is
absent from most of central Africa due to the near fixation of a mutation that inhibits the …

[HTML][HTML] Calcium-sensing receptor (CaSR), its impact on inflammation and the consequences on cardiovascular health

SS Sundararaman, EPC van der Vorst - International journal of molecular …, 2021 - mdpi.com
The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein
coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, …

Tiny-tail flash: Near-perfect elimination of garbage collection tail latencies in NAND SSDs

…, H Li, M Hao, MH Tong, S Sundararaman… - ACM Transactions on …, 2017 - dl.acm.org
Flash storage has become the mainstream destination for storage users. However, SSDs do
not always deliver the performance that users expect. The core culprit of flash performance …

[HTML][HTML] Stereotactic Body Radiotherapy (SBRT) for liver metastasis–clinical outcomes from the international multi-institutional RSSearch® Patient Registry

…, S Sundararaman, D D'Ambrosio, S Sharma… - Radiation …, 2018 - Springer
Background Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver
metastases in patients unsuitable for surgery. We investigated factors associated with …

[HTML][HTML] Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria

SA Sundararaman, LJ Plenderleith, W Liu… - Nature …, 2016 - nature.com
African apes harbour at least six Plasmodium species of the subgenus Laverania, one of
which gave rise to human Plasmodium falciparum. Here we use a selective amplification …

[PDF][PDF] MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

…, J Köhler, A Ogino, RS Nozawa, SK Sundararaman… - Cancer Cell, 2022 - cell.com
… Additionally, we included hydroxyurea or nocodazole as controls to induce S-phase or M-phase
cell-cycle arrest. We identified the median inhibition concentration (IC50) for each …

Fail-slow at scale: Evidence of hardware performance faults in large production systems

…, R Sears, C Golliher, S Sundararaman… - ACM Transactions on …, 2018 - dl.acm.org
Fail-slow hardware is an under-studied failure mode. We present a study of 114 reports of
fail-slow hardware incidents, collected from large-scale cluster deployments in 14 institutions. …