[HTML][HTML] Out of Africa: origins and evolution of the human malaria parasites Plasmodium falciparum and Plasmodium vivax
…, GH Learn, LJ Plenderleith, SA Sundararaman… - International journal for …, 2017 - Elsevier
… Although the mechanism(s) that maintain the dimorphic msp alleles in P. falciparum
remain largely unknown (Roy and Ferreira, 2015), some genes appear to be under balancing …
remain largely unknown (Roy and Ferreira, 2015), some genes appear to be under balancing …
[HTML][HTML] PCSK9: A multi-faceted protein that is involved in cardiovascular biology
SS Sundararaman, Y Döring, EPC van Der Vorst - Biomedicines, 2021 - mdpi.com
Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is secreted mostly by hepatocytes
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells. …
and to a lesser extent by the intestine, pancreas, kidney, adipose tissue, and vascular cells. …
Suppression of STING associated with LKB1 loss in KRAS-driven lung cancer
…, S Guo, R Yoshida, M Campisi, SK Sundararaman… - Cancer discovery, 2019 - AACR
… This effect is mediated at least in part by hyperactivation of DNMT1 and EZH2 activity
related to elevated S-adenylmethionine levels and reinforced by DNMT1 upregulation. Ectopic …
related to elevated S-adenylmethionine levels and reinforced by DNMT1 upregulation. Ectopic …
[HTML][HTML] African origin of the malaria parasite Plasmodium vivax
…, JA Malenke, SA Sundararaman… - Nature …, 2014 - nature.com
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is
absent from most of central Africa due to the near fixation of a mutation that inhibits the …
absent from most of central Africa due to the near fixation of a mutation that inhibits the …
[HTML][HTML] Calcium-sensing receptor (CaSR), its impact on inflammation and the consequences on cardiovascular health
SS Sundararaman, EPC van der Vorst - International journal of molecular …, 2021 - mdpi.com
The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein
coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, …
coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, …
Tiny-tail flash: Near-perfect elimination of garbage collection tail latencies in NAND SSDs
Flash storage has become the mainstream destination for storage users. However, SSDs do
not always deliver the performance that users expect. The core culprit of flash performance …
not always deliver the performance that users expect. The core culprit of flash performance …
[HTML][HTML] Stereotactic Body Radiotherapy (SBRT) for liver metastasis–clinical outcomes from the international multi-institutional RSSearch® Patient Registry
…, S Sundararaman, D D'Ambrosio, S Sharma… - Radiation …, 2018 - Springer
Background Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver
metastases in patients unsuitable for surgery. We investigated factors associated with …
metastases in patients unsuitable for surgery. We investigated factors associated with …
[HTML][HTML] Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria
SA Sundararaman, LJ Plenderleith, W Liu… - Nature …, 2016 - nature.com
African apes harbour at least six Plasmodium species of the subgenus Laverania, one of
which gave rise to human Plasmodium falciparum. Here we use a selective amplification …
which gave rise to human Plasmodium falciparum. Here we use a selective amplification …
[PDF][PDF] MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
…, J Köhler, A Ogino, RS Nozawa, SK Sundararaman… - Cancer Cell, 2022 - cell.com
… Additionally, we included hydroxyurea or nocodazole as controls to induce S-phase or M-phase
cell-cycle arrest. We identified the median inhibition concentration (IC50) for each …
cell-cycle arrest. We identified the median inhibition concentration (IC50) for each …
Fail-slow at scale: Evidence of hardware performance faults in large production systems
…, R Sears, C Golliher, S Sundararaman… - ACM Transactions on …, 2018 - dl.acm.org
Fail-slow hardware is an under-studied failure mode. We present a study of 114 reports of
fail-slow hardware incidents, collected from large-scale cluster deployments in 14 institutions. …
fail-slow hardware incidents, collected from large-scale cluster deployments in 14 institutions. …