The role of the PD-L1: PD-1 pathway in squamous cell carcinoma of the head and neck

DP Zandberg, SE Strome - Oral oncology, 2014 - Elsevier
… signaling is derived from the observation that these molecules are generally induced after
an initial antigen or receptor specific activation signal eg through the T cell receptor or FcγR’s, …

P Granule Assembly and Function in Caenorhabditis elegans Germ Cells

D Updike, S Strome - Journal of andrology, 2010 - Wiley Online Library
… Dr Susan Strome … Dr Susan Strome … could be used to investigate the establishment of
asymmetry or polarity within a cell (Strome and Wood, 1982, 1983). Indeed, much of the focus on P …

A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects

SE Strome, EA Sausville, D Mann - The oncologist, 2007 - academic.oup.com
… -life (8 days versus 23 days for IgG 1 s) probably due to different interactions between the two
… These monoclonal IgG 1 s allow for feasible administration and are most likely to promote …

A Map of the Interactome Network of the Metazoan C. elegans

…, SE Mango, WM Saxton, S Strome, S Van Den Heuvel… - Science, 2004 - science.org
To initiate studies on how protein-protein interaction (or “interactome”) networks relate to
multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

H Dong, SE Strome, DR Salomao, H Tamura… - Nature medicine, 2002 - nature.com
… for these observations is that receptor(s) other than PD-1 … and regulated by some unknown
factor(s) in the cultures. TRAIL-… that B7-H1 might bind receptor(s) other than PD-1 to transmit …

Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project

…, modENCODE Consortium, J Ahringer, S Strome… - Science, 2010 - science.org
We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

…, H Zincke, ML Blute, SE Strome… - Proceedings of the …, 2004 - National Acad Sciences
Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to
macrophage-lineage cells, providing a potential costimulatory signal source for regulation of …

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma

SE Strome, H Dong, H Tamura, SG Voss, DB Flies… - Cancer research, 2003 - AACR
In this report, we demonstrate that B7-H1, a B7 family molecule implicated in tumor immune
evasion, is constitutively expressed on 66% of freshly isolated squamous cell carcinomas of …

An assessment of histone-modification antibody quality

…, MI Kuroda, V Pirrotta, B Ren, S Strome… - Nature structural & …, 2011 - nature.com
We have tested the specificity and utility of more than 200 antibodies raised against 57 different
histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human …

Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos

S Strome, WB Wood - Cell, 1983 - cell.com
Germ-line granules in C. elegans embryos (P granules) can be visualized by immunofluorescence
microscopy using a monoclonal antibody. In mutant zygotes with abnormal spindle …