User profiles for S. Sankararaman

Sriram Sankararaman

- Verified email at cs.ucla.edu - Cited by 12665

SenthilKumar SankaraRaman

- Verified email at uhhospitals.org - Cited by 2779

Evidence for archaic adaptive introgression in humans

F Racimo, S Sankararaman, R Nielsen… - Nature Reviews …, 2015 - nature.com
As modern and ancient DNA sequence data from diverse human populations accumulate,
evidence is increasing in support of the existence of beneficial variants acquired from archaic …

The complete genome sequence of a Neanderthal from the Altai Mountains

…, N Patterson, F Jay, S Sankararaman, S Sawyer… - Nature, 2014 - nature.com
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We
show that her parents were related at the level of half-siblings and that mating among close …

The Simons genome diversity project: 300 genomes from 142 diverse populations

…, A Tandon, P Skoglund, I Lazaridis, S Sankararaman… - Nature, 2016 - nature.com
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300
individuals from 142 diverse populations. These genomes include at least 5.8 million base …

The genomic landscape of Neanderthal ancestry in present-day humans

S Sankararaman, S Mallick, M Dannemann, K Prüfer… - Nature, 2014 - nature.com
… To assess significance, we estimated Spearman’s correlation ρ and standard errors on ρ
using a block jackknife 37 with 10-Mb blocks (Supplementary Information section 8). …

Meet the meat alternatives: The value of alternative protein sources

A Thavamani, TJ Sferra, S Sankararaman - Current nutrition reports, 2020 - Springer
Purpose of Review Meat alternatives are non-animal-based proteins with chemical characteristics
and aesthetic qualities comparable to meat. The global increase in meat consumption …

Gut microbiome and its impact on obesity and obesity-related disorders

S Sankararaman, K Noriega, S Velayuthan… - Current …, 2023 - Springer
… Springer Nature or its licensor (eg a society or other partner) holds exclusive rights to this
article under a publishing agreement with the author(s) or other rightsholder(s); author self-…

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

…, S Sawyer, U Stenzel, J Kelso, M Lek, S Sankararaman… - Nature, 2014 - escholarship.org
Performing genetic studies in multiple human populations can identify disease risk alleles
that are common in one population but rare in others, with the potential to illuminate …

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

…, HE Wheeler, GL Wojcik, Y Zhou, S Sankararaman… - Nature …, 2023 - nature.com
… For a given individual, at each SNP s, we denote number of minor alleles from maternal
and paternal haplotypes as \(x_{s,M},x_{s,P} \in \{ 0,1\}\) and local ancestries as \(\gamma _{s,M},\…

[HTML][HTML] The date of interbreeding between Neandertals and modern humans

S Sankararaman, N Patterson, H Li, S Pääbo, D Reich - 2012 - journals.plos.org
… For all pairs of ascertained SNPs at a genetic distance x, we compute the statistic: Here S(x)
denotes the set of all pairs of ascertained SNPs that are at a genetic distance x, and D(i,j) …

[PDF][PDF] Colocalization of GWAS and eQTL signals detects target genes

…, JWJ Joo, M Bilow, JH Sul, S Sankararaman… - The American Journal of …, 2016 - cell.com
… We assume an ‘‘additive’’ Fisher’s polygenic model, which is widely used by the GWAS
community. In Fisher’s polygenic model, the phenotypes follow a normal distribution. The …