Evidence for archaic adaptive introgression in humans
As modern and ancient DNA sequence data from diverse human populations accumulate,
evidence is increasing in support of the existence of beneficial variants acquired from archaic …
evidence is increasing in support of the existence of beneficial variants acquired from archaic …
The complete genome sequence of a Neanderthal from the Altai Mountains
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We
show that her parents were related at the level of half-siblings and that mating among close …
show that her parents were related at the level of half-siblings and that mating among close …
The Simons genome diversity project: 300 genomes from 142 diverse populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300
individuals from 142 diverse populations. These genomes include at least 5.8 million base …
individuals from 142 diverse populations. These genomes include at least 5.8 million base …
The genomic landscape of Neanderthal ancestry in present-day humans
… To assess significance, we estimated Spearman’s correlation ρ and standard errors on ρ
using a block jackknife 37 with 10-Mb blocks (Supplementary Information section 8). …
using a block jackknife 37 with 10-Mb blocks (Supplementary Information section 8). …
Meet the meat alternatives: The value of alternative protein sources
A Thavamani, TJ Sferra, S Sankararaman - Current nutrition reports, 2020 - Springer
Purpose of Review Meat alternatives are non-animal-based proteins with chemical characteristics
and aesthetic qualities comparable to meat. The global increase in meat consumption …
and aesthetic qualities comparable to meat. The global increase in meat consumption …
Gut microbiome and its impact on obesity and obesity-related disorders
S Sankararaman, K Noriega, S Velayuthan… - Current …, 2023 - Springer
… Springer Nature or its licensor (eg a society or other partner) holds exclusive rights to this
article under a publishing agreement with the author(s) or other rightsholder(s); author self-…
article under a publishing agreement with the author(s) or other rightsholder(s); author self-…
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
Performing genetic studies in multiple human populations can identify disease risk alleles
that are common in one population but rare in others, with the potential to illuminate …
that are common in one population but rare in others, with the potential to illuminate …
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals
… For a given individual, at each SNP s, we denote number of minor alleles from maternal
and paternal haplotypes as \(x_{s,M},x_{s,P} \in \{ 0,1\}\) and local ancestries as \(\gamma _{s,M},\…
and paternal haplotypes as \(x_{s,M},x_{s,P} \in \{ 0,1\}\) and local ancestries as \(\gamma _{s,M},\…
[HTML][HTML] The date of interbreeding between Neandertals and modern humans
… For all pairs of ascertained SNPs at a genetic distance x, we compute the statistic: Here S(x)
denotes the set of all pairs of ascertained SNPs that are at a genetic distance x, and D(i,j) …
denotes the set of all pairs of ascertained SNPs that are at a genetic distance x, and D(i,j) …
[PDF][PDF] Colocalization of GWAS and eQTL signals detects target genes
…, JWJ Joo, M Bilow, JH Sul, S Sankararaman… - The American Journal of …, 2016 - cell.com
… We assume an ‘‘additive’’ Fisher’s polygenic model, which is widely used by the GWAS
community. In Fisher’s polygenic model, the phenotypes follow a normal distribution. The …
community. In Fisher’s polygenic model, the phenotypes follow a normal distribution. The …