Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

… By pooling data from ~1.5 million people, our approach is statistically more powerful than
single-trait analyses and identifies more than 500 genetic loci. The loci were enriched for …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although
genome-wide association studies have identified PAU risk genes, the genetic architecture …

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes.
In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (…

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

… The moderate variability in heritability estimates is to be expected because heritability is not
only a property of a trait but is also influenced by differences among samples, methodology, …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta-…

… We estimated pairwise r g s with OUD for 40 published phenotypes using LDSC 23 . OUD
showed significant r g s with 21 traits. As expected, the strongest positive correlations were …