[HTML][HTML] Molecular aspects of tumour hypoxia

SE Rademakers, PN Span, JHAM Kaanders… - Molecular …, 2008 - Elsevier
Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its
critical role in radio- and chemoresistance and its significance as an adverse prognostic …

[HTML][HTML] Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease

…, BK Shell, E Evans, MC De Jong, S Rademakers… - Cell, 1996 - cell.com
… We decided to search directly for a human homolog of S. cerevisiae Rad1 and test it for
possible correcting activity in XP-F and rodent group 4 and 11 cells and extracts. …

Action of DNA repair endonuclease ERCC1/XPF in living cells

AB Houtsmuller, S Rademakers, AL Nigg… - Science, 1999 - science.org
… before and 4 s after spot bleaching (which takes 4 s) was … 4 s of spot bleaching and lost
fluorescence. The remaining fluorescence was uniformly redistributed within the nucleus 4 s after …

[PDF][PDF] Accelerated radiotherapy with carbogen and nicotinamide for laryngeal cancer: results of a phase III randomized trial

GO Janssens, SE Rademakers… - Journal of clinical …, 2012 - academia.edu
… A B S T R A C T … The author(s) indicated no potential conflicts of interest. … Robbins KT,
Medina JE, Wolfe GT, et al: Standardizing neck dissection terminology: Official report of the …

[HTML][HTML] The Cockayne syndrome B protein, involved in transcription‐coupled DNA repair, resides in an RNA polymerase II‐containing complex

AJ van Gool, E Citterio, S Rademakers, R van Os… - The EMBO …, 1997 - embopress.org
… Superdex S‐200 gel filtration was performed under physiological conditions, identical to …
Similar findings were made on Sephacryl S‐300 and S‐500 columns (data not shown). …

[HTML][HTML] Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

SE Rademakers, J Lok, AJ van der Kogel, J Bussink… - BMC cancer, 2011 - Springer
Background The cellular response of malignant tumors to hypoxia is diverse. Several
important endogenous metabolic markers are upregulated under hypoxic conditions. We …

Vasopressin/Oxytocin-Related Signaling Regulates Gustatory Associative Learning in C. elegans

…, E Meelkop, L Temmerman, N Suetens, S Rademakers… - Science, 2012 - science.org
Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology,
including water balance and reproduction. Although these neuropeptides also modulate …

[HTML][HTML] XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription

…, S Rademakers, W Vermeulen, S Kamiuchi… - Journal of Biological …, 2000 - ASBMB
… The SYF1 gene had been identified as a synthetic lethal mutant with the CDC40/PRP17gene,
which is involved in S phase progression of the cell cycle and pre-mRNA splicing in S. …

Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions

S Rademakers, M Volker, D Hoogstraten… - … and Cellular Biology, 2003 - Taylor & Francis
… These findings raise the question as to what causes the entry of RPA into the NER complex,
ie, which protein(s) or protein function(s) is necessary and indispensable for RPA to be …

Differences in metabolism between adeno-and squamous cell non-small cell lung carcinomas: spatial distribution and prognostic value of GLUT1 and MCT4

…, J Lok, HFM van der Heijden, SE Rademakers… - Lung cancer, 2012 - Elsevier
BACKGROUND: Hypoxia leads to changes in tumor cell metabolism such as increased
glycolysis. In this study, we examined the spatial distribution of the glycolysis and hypoxia …