Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers. …

… S-LDSC is designed to test for enrichment of an annotation using variants genome-wide, …
However, it is worth noting that studies performing S-LDSC analyses often correct for multiple …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

… We obtained Capan-1 pancreatic ductal adenocarcinoma cell lines from ATCC and cultured
them using Iscove’s modified Dulbecco’s medium with 20% fetal bovine serum, 100 units/ml …

… We allowed 30 s pauses on ice between each 30 s session, using pulse settings with 0.5 s
… 200 μl of RIPA Dilution buffer was added to the pellet and sonicated 3 × 30 s. The sample …

… ) and provided improved resolution by linking complex traits to specific cell type(s) (Figure
S6). Further, for 160 additional traits, … We thank S. Kuan for sequencing support. We thank B. …

… ; ii) at least 1 spike/s; and iii) 1 s away from any other network events. The first … s before to
2.5 s after the peak was collected as the network event, as events almost always subsided 2.5 s …

… the nearest s landmarks in the reference dataset in the joint embedding space. Nearest
anchors are then weighted based on their distance to the cell c over the distance to the s-th …

… Chromatin was sheared using a Bioruptor (Diagenode, Liege, Belgium) with 30 high-energy
cycles (30 s on/30 s off) to an average size of 200–400 bp. Lysates were diluted 1:10 with …

… From our CRISPRi and ChIP-Seq studies, we discovered that HERV-H’s ability to form TAD
boundaries is highly dependent on transcription, and more specifically RNA polymerase II (…