Importance The US Preventive Services Task Force (USPSTF) is updating its 2013 lung cancer
screening guidelines, which recommend annual screening for adults aged 55 through 80 …

Lung cancer remains the leading cause of cancer related deaths worldwide. Lung cancer
screening using low-dose computed tomography (LDCT) has been shown to reduce lung …

Background Metastatic breast cancer (MBC) treatment has changed substantially over time,
but we do not know whether survival post-metastasis has improved at the population level. …

Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …

Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis.
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …

Background We used modeling techniques to assess the relative and absolute
contributions of screening mammography and adjuvant treatment to the reduction in breast-cancer …

The ability to analyze multiple single-cell parameters is critical for understanding cellular
heterogeneity. Despite recent advances in measurement technology, methods for analyzing …

… , but 3 (models E, S, and W) use tumor size and tumor growth. The models also differ by
whether treatment affects the hazard for death from breast cancer (models G, S, and D), results …

Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen
receptor (CAR) T cell therapies targeting CD19 experience disease progression, and …

Background: The optimum screening policy for lung cancer is unknown. Objective: To identify
efficient computed tomography (CT) screening scenarios in which relatively more lung …