… is similar to that of the autosomes, we inferred that the Vindija 33.19 individual is a female, …
fragments sequenced is less than 1%. After genotyping, this will result in contamination that …

Neanderthals and Denisovans are extinct groups of hominins that separated from each other
more than 390,000 years ago 1 , 2 . Here we present the genome of ‘Denisova 11’, a bone …

… Here an overview of currently available methods highlighting their strengths and weaknesses
is provided, and a classification based on the signals used to estimate contamination is …

… In addition, the Y-chromosome diversity is an order of magnitude lower than the
mitochondrial diversity, a pattern that we found is best explained by female migration between …

We sequenced the genome of a Neandertal from Chagyrskaya Cave in the Altai Mountains,
Russia, to 27-fold genomic coverage. We show that this Neandertal was a female and that …

… We then review what is known about the Denisovan phenotype. Finally, we highlight how
our understanding of Denisovans yields valuable knowledge about our own evolutionary …

… insights into their culture and social hierarchy, and is relevant for downstream genetic
analyses. However, estimating relatedness from ancient DNA is difficult due to low-coverage, …

… Using simulations, we show that the method is able to detect ancient events of positive
selection and that it can differentiate those from background selection. Applying our method to the …

… We estimate that the probability for this late mtDNA replacement is nearly identical to the
admixture rate, ie, more than 5% admixture is required to reach a probability of 5% for such an …

… This approach is particularly well-tailored for studying the mitochondrial genome, because
it is an extensively studied, non-recombining locus that is often available at high coverage. In …