… ‘Design’ tool of WMD implements two main steps: (i) optimization of small RNAs for maximal
effectiveness, and (ii) selection of those with highest specificity for the intended target gene(s…

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

… In addition, we have not yet explored the simultaneous use of several amiRNAs against
the same target(s), which is commonplace with siRNAs and which may further increase the …

The plant Arabidopsis thaliana occurs naturally in many different habitats throughout
Eurasia. As a foundation for identifying genetic variation contributing to adaptation to diverse …

… mutation rate with the rate at synonymous sites and introns, which are less likely to be
under strong selection, and we still detected a significant deficit of mutations in the latter (Fisher’s …

We report the 207-Mb genome sequence of the North American Arabidopsis lyrata strain MN47
based on 8.3× dideoxy sequence coverage. We predict 32,670 genes in this outcrossing …

To the Editor: Traditional strategies for identification of causal mutations involve two discrete
steps: recombinant genotyping and candidate gene sequencing. To dramatically speed up …

First published in 1998. This is Volume III of the twenty-one in the Race, Class and Social
Structure series. Looking at social consciousness, in part one it focuses on biblical legends o …

The genomes of individuals from the same species vary in sequence as a result of different
evolutionary processes. To examine the patterns of, and the forces shaping, sequence …