… nucleotides leads to a change in the model’s prediction. These changes are collected for all
… ’s predictions from the original sequence. c | Calculating the gradient of the model’s output …

Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …

Nanotechnology, although still in the early stages, has the potential to revolutionize the early
diagnosis, treatment, and monitoring of disease progression. Technological application of …

Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

… GeneMANIA then extends the user’s list with genes that are functionally similar, or have …
with those in the query list based on GeneMANIA’s large and diverse data collection. …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-gene
pairs for synthetic genetic interactions, generating quantitative genetic interaction profiles …

… between samples s 1 , s 2 if and only if and the most likely mixing proportion is estimated to
be argmax α L c (s 1 , s 2 , α). We determine that the cell contains only a single individual s if, …

… S by setting all its elements to zero, except for its diagonal elements, which we specify by
setting S … unregularized version of this problem, we simply set all of the elements of S to zero. …