… S. Nik-Zainal is listed as a co-inventor on multiple patent filings related to the application of
mutational … S. Morganella is funded by core funds from the Wellcome Trust Sanger Institute. …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

… ’s or SigProfiler’s analysis of the PCAWG genome data. SignatureAnalyzer’s reference …
SigProfiler’s reference analysis was based on strand-agnostic SBSs in the context of one 5…

Approximately 1–5% of breast cancers are attributed to inherited mutations in BRCA1 or
BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other …

Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns
that hint at the causative origins of cancer. We examined mutational signatures in 324 WGS …

… Pearson’s correlations were separately applied to assess the relationship between the …
The Pearson’s test showed low P values for strong correlations across replication time. On the …

… an eleven genes network from yeast S. cerevisiae cell cycle, … Entry into S phase requires
the activation of the protein … activates DNA synthesis genes and S-phase cyclin genes CLB5 …

Whole genome sequencing of human tumours has revealed distinct patterns of mutation
that hint at the causative origins of cancer. Experimental investigations of the mutations and …

Mutational signatures are patterns of mutations that arise during tumorigenesis. We present
an enhanced, practical framework for mutational signature analyses. Applying these …

… The mechanism(s) underlying this amplification of transcriptional strand bias in exons is …
We operationally defined "realistic" as corresponding to either SA’s or SP’s analysis of the …