… -plate assay, in which one plate was inoculated with S. aureus carrying the antisense
construct and the other plate with an S. aureus control. Different inhibition halos in the two plates …

There is an increased need for new drug leads to treat diseases in humans, animals and
plants. A dramatic example is represented by the need for novel and more effective antibiotics …

Drug-resistant bacterial pathogens pose an urgent public-health crisis. Here, we report the
discovery, from microbial-extract screening, of a nucleoside-analog inhibitor that inhibits …

The anti-hyperglycaemic drug metformin has important anticancer properties as shown by the
direct inhibition of cancer cells proliferation. Tumor cells avidly use glucose as a source for …

… We initially tested NAI-112’s ability to prevent pain-related behaviors elicited in mice by
intraplantar injection of the chemical irritant formalin. The formalin test is a tonic model of …

… Maffioli … Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides
and its application to synthesis of antidepressant (1 S ,2 R )-tranylcypromine. Tetrahedron …

… ), is a new type AI lantibiotic produced by the actinomycete Microbispora s. ATCC PTA-5024,
which is active against multidrug-resistant Gram-positive pathogens, including methicillin-…

Metformin causes an AMP/ATP ratio increase and AMP‐activated protein kinase (AMPK)
activation. Since caveolin‐1 (Cav‐1) plays a role in AMPK activation and energy balance, we …

… a similar C-terminal ring topology with the consensus sequence S-(F/W/N)-(N/C)-S-(F/Y/W/N)-…
The authors declare the following competing financial interest(s): Sonia Maffioli, Stefano …

10.7554/eLife.02450.001 Using a combination of genetic, biochemical, and structural approaches,
we show that the cyclic-peptide antibiotic GE23077 (GE) binds directly to the bacterial …