PURPOSE Evidence-based guidelines recommend cascade genetic counseling and testing
for hereditary cancer syndromes, providing relatives the opportunity for early detection and …

… ’s cancer is identical to the inherited germline sequence. Although some sequence variants
found in a patient’s … It is not possible to know a priori whether a variant identified in a patient’s …

Purpose Several professional organizations recommend universal genetic assessment for
people with ovarian cancer as identifying pathogenic variants can affect treatment, prognosis, …

OBJECTIVE To assess the effect of a tissue-engineered human dermis (Dermagraft) in
healing diabetic foot ulcers. RESEARCH DESIGN AND METHODS This controlled prospective …

A common feature of all the known cancer genetic syndromes is that they predispose only to
selective types of malignancy. However, many of the genes mutated in these syndromes are …

… were primarily represented by S. cerevisiae. Among fungi broadly assigned as non-…
albicans and S. cerevisiae were each at the center of two anticorrelated co-abundance clusters …

Importance Guidelines for cancer genetic testing based on family history may miss clinically
actionable genetic changes with established implications for cancer screening or prevention…

DNA mismatch repair is important because of its role in maintaining genomic integrity and
its association with hereditary non-polyposis colon cancer (HNPCC). To identify new human …

MutL homolog 3 (Mlh3) is a member of a family of proteins conserved during evolution and
having dual roles in DNA mismatch repair and meiosis 1, 2. The pathway in eukaryotes …

Introduction Plummeting sequencing costs have led to a great increase in the number of
personal genomes. Interpreting the large number of variants in them, particularly in noncoding …