Fas-associated death domain protein (FADD) and caspase-8 (casp8) are vital intermediaries
in apoptotic signaling induced by tumor necrosis factor family ligands. Paradoxically, …

… HT1080 (human fibrosarcoma) cells were maintained in Dulbecco’s modified Eagle’s medium
(DMEM) supplemented with 10% fetal calf serum and glutamine. HT1080 polyclonal cell …

… ’s pauses. Further experiments showed that the calcium signals that control the cell’s movements
… , in which T cells incorrectly recognize the body’s own antigens as signs of an infection. …

… Analysis of the location in the Bak structure of both the S/T … (s) or they may be involved in
pathways that have yet to be linked to apoptosis signalling. Overexpression of the Bak kinase(s) …

… 40 s, 55 mC (CDα), 62 mC (CDδ) or 60 mC (CDε) for 1 min 30 s, and 72 mC for 1 min 30 s
(… of Ham’s F10 medium at a density of 2i10' cells\well and grown for 24 h before transfection. …

The extrinsic, or death receptor, pathway integrates apoptotic signals through the protease
caspase-8 (casp8). Beyond cell death regulation, non-apoptotic functions of casp8 include its …

… Gladbach, Germany) according to manufacturer’s instructions. PBLs were first suspended in
… CD19 + B cells were isolated by positive selection according to manufacturer’s instructions (…

Abstract Development of metastasis causes the most serious clinical consequences of cancer
and is responsible for over 90 % of cancer-related deaths. Hence, a better understanding …

The GAGA box of the rat serine protease inhibitor 2 (spi 2) genes not only acts as a basal
promoter element, but also mediates transcriptional activation by growth hormone and …

Fas-associated death domain protein (FADD) constitutes an essential component of TNFR-induced
apoptotic signaling. Paradoxically, FADD has also been shown to be crucial for …