A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS)

…, S Jacobsen, D Jayne, A Kuhn, V Le Guern… - Annals of the …, 2017 - ard.bmj.com
Objectives Treat-to-target recommendations have identified ‘remission’ as a target in systemic
lupus erythematosus (SLE), but recognise that there is no universally accepted definition …

The Complex Quorum Sensing Circuitry of Burkholderia thailandensis Is Both Hierarchically and Homeostatically Organized

S Le Guillouzer, MC Groleau, E Déziel - MBio, 2017 - Am Soc Microbiol
… pseudomallei (12), is commonly used as a surrogate model for the study of B. pseudomallei,
which is considered a potential bioterrorism agent and whose manipulation is consequently …

ScmR, a Global Regulator of Gene Expression, Quorum Sensing, pH Homeostasis, and Virulence in Burkholderia thailandensis

S Le Guillouzer, MC Groleau, F Mauffrey… - Journal of …, 2020 - Am Soc Microbiol
… , is complex. We found that the LysR-type transcriptional regulator, ScmR, which is highly …
/survival factors in the Burkholderia genus, is a global regulator mediating gene expression …

[HTML][HTML] Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and N-Acyl-Homoserine Lactone Signaling in a Burkholderia cepacia Complex Clinical Strain

…, S Le Guillouzer, A Miomandre, L Vial, S Milot… - Frontiers in …, 2017 - frontiersin.org
… It is noteworthy that we observe the same scenario in an hmqA- mutant from HMAQ-producer
strain B. thailandensis E264 (Le Guillouzer et al., unpublished). This result was unexpected …

Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes

D Escande, D Thuringer, S Le Guern, J Courteix… - Pflügers Archiv, 1989 - Springer
… Here, we show that this property is also shared by RP 49356 and pinacidil, two molecules
which are structurally different from cromakalim (Fig. I). Our findings strongly suggest that the …

RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of …

…, M Vuilhorgne, MW Debono, S Le Guern… - … of Pharmacology and …, 2001 - ASPET
… RPR 119990 is a potent anticonvulsant in the supramaximal electroshock in the mouse
with an ED 50 of 2.3 mg/kg 1 h post sc administration, giving it a workably long action. …

Hydroxychloroquine: a multifaceted treatment in lupus

…, B Dunogue, N Morel, V Le Guern… - La Presse Médicale, 2014 - Elsevier
… that HCQ, which is inexpensive, has a protective effect on survival in SLE patients. Thanks
to the … In conclusion, we will review for which SLE patients this treatment is most adequate. …

Adherence to treatment in systemic lupus erythematosus patients

…, J Pouchot, G Guettrot-Imbert, V Le Guern… - Best practice & research …, 2013 - Elsevier
… by patients, the physician global assessment is highly subjective and inaccurate (including
in our experience), and failure to attend scheduled visits is not easy to assess routinely and …

Indeno[1,2-b]pyrazin-2,3-diones: A New Class of Antagonists at the Glycine Site of the NMDA Receptor with Potent in Vivo Activity

…, F Herman, A Imperato, S Le Guern… - Journal of medicinal …, 2000 - ACS Publications
… The reaction mixture is stirred for 4 h at room temperature and is then poured into 300 mL
of distilled water. The reaction medium is cooled to 5 C and then acidified to pH = 1 by adding …

Two rsaM Homologues Encode Central Regulatory Elements Modulating Quorum Sensing in Burkholderia thailandensis

S Le Guillouzer, MC Groleau, E Déziel - Journal of Bacteriology, 2018 - Am Soc Microbiol
… This is consistent with our proposal that 3OHC 8 -HSL is produced by BtaI2 at the expense
of 3OHC 10 -HSL in the stationary phase (16). Since the transcription of neither btaI3 nor …