Analysis procedures are needed to extract useful information from the large amount of gene
expression data that is becoming available. This work describes a set of analytical tools and …

The goal of the International HapMap Project is to determine the common patterns of DNA
sequence variation in the human genome and to make this information freely available in the …

… Manta discovers variants from a sequencing assay’s paired and split… We describe Manta’s
methods and compare with … Manta’s workflow is designed for high parallelization on individual …

Scanners for conventional microarrays typically have imaging spot sizes in the range of 3–5
microns, insufficient to resolve the~ 5-micron-spaced features on the randomly assembled …

We have developed a simple and efficient algorithm to identify each member of a large
collection of DNA-linked objects through the use of hybridization, and have applied it to the …

… Considerable effort is expended to protect today’s children from lead exposure, but there
is little evidence on the harms past lead exposures continue to hold for yesterday’s children, …

… Kruglyak and E. Hubbell for valuable comments and feedback. We were supported in
part by NSF grant DBI 9504393 and NIH grant R01 GM36230. We thank S. Tavaré and M. …

Improvement of variant calling in next-generation sequence data requires a comprehensive,
genome-wide catalog of high-confidence variants called in a set of genomes for use as a …

An ultrafast DNA sequence aligner (Isaac Genome Alignment Software) that takes advantage
of high-memory hardware (>48 GB) and variant caller (Isaac Variant Caller) have been …

We present avidity sequencing, a sequencing chemistry that separately optimizes the
processes of stepping along a DNA template and that of identifying each nucleotide within the …