This document updates the recommendations on the management of Philadelphia
chromosome-negative myeloproliferative neoplasms (Ph-neg MPNs) published in 2011 by the …

While much is known about aberrant pathways affecting cell growth and apoptosis, our
understanding of another critical step of neoplastic transformation, differentiation arrest, remains …

The Philadelphia-negative myeloproliferative neoplasms (MPNs) are clonal disorders
involving hematopoietic stem and progenitor cells and are associated with myeloproliferation, …

Introduction: The functions of large noncoding RNAs (ncRNAs) have remained elusive in
many cases. Metastasis-Associated-in-Lung-Adenocarcinoma-Transcript-1 (MALAT-1) is an …

Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to
kinase inhibitors and responsible for minimal residual disease in treated patients. We …

Both PU.1 (also called SFPI1), an Ets-family transcription factor, and AML1 (also called
RUNX1), a DNA-binding subunit of the CBF transcription factor family, are crucial for the …

Background About 50% of patients (age ≥60 years) who have acute myeloid leukaemia
and are otherwise medically healthy (ie, able to undergo intensive chemotherapy) achieve a …

The success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML)
depends on the requirement for BCR-ABL1 kinase activity in CML progenitors. However, …

Background The PROUD-PV and CONTINUATION-PV trials aimed to compare the novel
monopegylated interferon ropeginterferon alfa-2b with hydroxyurea, the standard therapy for …

To develop murine models of leukemogenesis, a series of transgenic mice expressing BCR-ABL
in different hematopoietic cell subsets was generated. Here we describe targeted …