Highlights • Aptamers are oligonucleotides that bind targets conceptually similar to antibodies.
• Spiegelmers are plasma-stable, nonimmunogenic, mirror-image (l-configured) aptamers…

… Sven Klussmann Dr.… (Reprinted with permission from the Nature Publishing Group and
S. Klussmann, A. Nolte, R. Bald, VA Erdmann, JP Fürste, Nat. …

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Single-stranded mirror-image oligonucleotides, which are highly resistant to nuclease
degradation and are capable of tightly and specifically binding to protein targets to inhibit their …

A 58-mer L-RNA ligand that binds to naturally occurring D-adenosine with a dissociation
constant of 1.7 μM in solution was identified from a combinatorial library employing mirror-…

Rationale: Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and
vascular remodeling. Recent studies have revealed that immune and inflammatory …

… To study whether stimulation of CD95 triggers b-catenin’s transcriptional activity, we …
catenin’s transcriptional reporter activity. LiCl, a known inhibitor of GSK3b and inducer of b-catenin’s …

… Here, the number of sequences forming structure S is denoted by mS, the number of neutral
sequences forming S in the one-error neighborhood of the sequence Ik is n(S)k, and the …

… The predicted secondary structure of the conserved motif was confirmed by enzymatic probing
with nucleases T, T, S, and V, under native and denaturing conditions". Circular dichroism …

… with periodic acid–Schiff’s reagent. Stains show representative … d Periodic acid–Schiff’s
stains were scored for extent of … We thank S. Vonhoff and the chemistry group at NOXXON …