The Microarchitecture of C. elegans Behavior during Lethargus: Homeostatic Bout Dynamics, a Typical Body Posture, and Regulation by a Central Neuron

S Iwanir, N Tramm, S Nagy, C Wright, D Ish, D Biron - sleep, 2013 - academic.oup.com
… with a homeostatic process (S) to regulate sleep-wake cycles. The process S represents an
… The time-course of S can be inferred from measurements of slow wave activity (SWA), ie, …

[HTML][HTML] Serotonin-dependent kinetics of feeding bursts underlie a graded response to food availability in C. elegans

KS Lee, S Iwanir, RB Kopito, M Scholz… - Nature …, 2017 - nature.com
… of the environment and of the animal’s behaviour and characterize the distinct roles of …
along with the relative simplicity of the worm’s neuronal circuitry and anatomy, open the way …

[PDF][PDF] GIRK channel activation involves a local rearrangement of a preformed G protein channel complex

I Riven, S Iwanir, E Reuveny - Neuron, 2006 - cell.com
… Here, we show that the key activation entity, the Gbg complex, is closely associated with
the channel’s cytosolic domains at rest and that upon GPCR activation the Gbg dimer …

Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms

S Nagy, N Tramm, J Sanders, S Iwanir, IA Shirley… - Elife, 2014 - elifesciences.org
… of body posture at high temporal and spatial resolutions (Iwanir et al., 2013; Nagy et al.,
2014). Using this analysis and a 15 s weak light stimulus, we measured the durations of bouts of …

[PDF][PDF] Glia modulate a neuronal circuit for locomotion suppression during sleep in C. elegans

M Katz, F Corson, S Iwanir, D Biron, S Shaham - Cell reports, 2018 - cell.com
… Images were captured for 5 min at 4 frames/s and analyzed using a custom Java code for
AVE activity and position within the microfluidic device (see the Supplemental Experimental …

[HTML][HTML] Serotonin promotes exploitation in complex environments by accelerating decision-making

S Iwanir, AS Brown, S Nagy, D Najjar, A Kazakov… - BMC biology, 2016 - Springer
Background Fast responses can provide a competitive advantage when resources are
inhomogeneously distributed. The nematode Caenorhabditis elegans was shown to modulate …

Adrenaline-induced hyperpolarization of mouse pancreatic islet cells is mediated by G protein-gated inwardly rectifying potassium (GIRK) channels

S Iwanir, E Reuveny - Pflügers Archiv-European Journal of Physiology, 2008 - Springer
… 30 s at 94C, 30 s at 55C, 60 s at 72C] for 15 cycles and 10 min in 72C. RT-PCR product
locations (from CDS start) for the different gene products were: GIRK1, 435–1,100; GIRK2a, 914–…

[PDF][PDF] A memory circuit for coping with impending adversity

Y Eliezer, N Deshe, L Hoch, S Iwanir, CO Pritz… - Current Biology, 2019 - cell.com
… during the 10 s after the switch and the mean activity during the 10 s prior to the switch (for
the AWC neurons), and the difference between the 20 s after the switch and the 20 s prior to …

[HTML][HTML] Irrational behavior in C. elegans arises from asymmetric modulatory effects within single sensory neurons

S Iwanir, R Ruach, E Itskovits, CO Pritz… - Nature …, 2019 - nature.com
… variance in worm’s preferences (RCI, BCI), we chose 46 different pairs of stimuli (consisted
of odorants, tastants, the buffer null option, and which span various magnitudes of CI’s), and …

Reduced activity of GIRK1‐containing heterotetramers is sufficient to affect neuronal functions, including synaptic plasticity and spatial learning and memory

…, I Karbat, M Tsoory, S Fine, S Iwanir… - The Journal of …, 2021 - Wiley Online Library
… for up to 90 s. Each mouse was allowed to remain on the platform for 15 s and was then …
the platform within the 90 s, it was manually placed on the platform for 15 s. Memory was …